The Potential Diagnostic Value of Immune-Related Genes in Interstitial Fibrosis and Tubular Atrophy after Kidney Transplantation

Figure 2

Identification of IF/TA-related DE-IRGs. (a and b) DEGs were identified from the GSE76882 and GSE120495 datasets. In the figures, each point represents a gene, and the green and red points represent the significantly differentially expressed genes, and the red points represent upregulated differentially expressed genes, while the green points represent downregulated differentially expressed genes, and the black points represent no significantly differentially expressed genes. (c) IRGs from the ImmPort database were compared to DEGs from above two datasets. The red box in the figure is the final IFTA DE-IRGs, including 6 upregulated differential immunity genes and 3 downregulated differential immunity genes. (d and e) The heatmap of EGF, ANGPTL3, APOH FCGR2B, CXCL6, HLA-DQA2, SLPI, LTF, and LCN2 genes in the IF/TA group. Each small square represents each gene, and its color represents the size of the gene expression. The greater the expression, the deeper the color (red is high expression and blue is low expression). The first line represents sample grouping, lake blue represents control sample, and pink represents IF/TA sample. Each row represents the expression of each gene in different samples, and each column represents the expression of all genes in each sample.

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