Comprehensive Analysis of the Expression and Prognostic Value of LMAN2 in HER2+ Breast Cancer

Figure 2

The association between LMAN2 expression and clinicopathological characteristics. (a) The LMAN2 mRNA expression in breast cancer by UALCAN. LMAN2 expression was linked to clinicopathologic characteristics, such as clinical stage, race, sex, p53 mutation status, age, cancer subclasses, distant metastases, and menopause. (b) Analysis of LMAN2 expression in breast cancer using the bc-GenExMiner v4.7 database. Differential expression of LMAN2 in patients with ER-negative and ER-positive, HER2-negative and HER2-positive, lymph node metastasis-positive and lymph node metastasis-negative, p53 mutation-positive and p53 mutation-negative, nontriple negative breast cancer (non-TNBC) and TNBC, nonbasal-like and basal-like, NPI1 vs. NPI2 vs. NPI3, SBR1 vs. SBR2 vs. SBR3, IDC vs. ILC vs. IDC/ILC vs. “mucinous” vs. micropapillary, luminal A vs. HER2-positive vs. luminal B vs. basal-like, and ER-positive/PR-positive vs. ER-negative/PR-positive vs. ER-negative/PR-negative vs. ER-positive/PR-negative breast cancer patients using bc-GenExMiner v4.7. (c) The protein expression of LMAN2 in several subtypes of breast cancer patients as examined with the help of the UALCAN database. Association of LMAN2 expression with clinicopathological characteristics, including clinical stage, race, age, cancer subclasses, histological type, and cancer status. (d) Spatial transcriptomics assessment of gene expression in tissue sections. This work produced high-quality RNA-sequencing data on human breast cancer by importing histologic sections on arrayed reverse transcriptional primers with unique positional barcodes. The data included maintained two-dimensional position data from the histological sections. (e) The protein expression of LMAN2 in breast tumor and normal samples (HPA). (f) The LMAN2 expression in different breast cancer cells by GOBO. (g) The expression of LMAN2 in different breast cancer cells by CCLE and the expression distribution of LMAN2 in different cell lines. The gene expression is shown by the horizontal axis in the figure. The distinct cell lines are represented by the ordinate. The expression level is shown by the dot size and the various colors used in the illustration (; ; ).

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