Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases

Table 2

Examples of intestinal viruses and their role in maintaining gut health.

Virus	Mechanism	Outcome	References
Caudovirales	Colonization of donor-derived Caudovirales taxa in recipients.	Effective treatment of recurrent C. difficile after fecal microbiota transplant (FMT)	[35]
Lymphocytic choriomeningitis virus (LCMV)	Infects and replicate in lymphocytes, thereby disordering their function and favoring immune suppression	Prevention of type I diabetes in NOD mice	[47]
Murine gammaherpesvirus 68	Prevents the development and progression of autoimmune lupus-like disease in mice	Inhibits the activation of T cells, B cells, and dendritic cells.	[48]
Murine cytomegalovirus	Latent infection protects host from intracellular bacterial infection such as L. monocytogenes	Latent infection triggers elevated levels of IFN-γ and TNF-α by activated macrophages	[49]