Deletion of Mettl3 at the Pro-B Stage Marginally Affects B Cell Development and Profibrogenic Activity of B Cells in Liver Fibrosis

Figure 2

Loss of Mettl3 in Cd19⁺ cells has minimal effects on mouse development and B cell distribution in peripheral. (a) Body weight of control and Mettl3 cKO littermates at different time points after birth (/group). (b) The ratio of liver weight to body weight for mice in indicated groups (/group). (c) The ratio of spleen weight to body weight for mice in indicated groups (/group). (d)–(g) Representative flow cytometry plots (left) and quantification (right) for B cell marker CD19 of lymphocytes isolated from peripheral blood (d) (/group), peritoneal cavity (e) (/group), liver (f) (/group), and spleen (g) (/group) at indicated groups. (h) Representative photographs of HE staining of the spleen (left) and liver (right) of WT and Mettl3 cKO mice. and 50 μm as indicated. Data in (c and g) were presented as with the indicated significance (; student’s -test).

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