Deletion of Mettl3 at the Pro-B Stage Marginally Affects B Cell Development and Profibrogenic Activity of B Cells in Liver Fibrosis

Figure 3

Loss of Mettl3 does not affect B cell development and maturation in bone marrow. (a, b) Representative flow cytometry plots (a) and quantification (b) of B cells in the bone marrow of indicated groups (/group). (c)–(e) Representative flow cytometry plots of B cell subpopulations in the bone marrow of WT and Mettl3 cKO mice. B220⁺CD43⁺ lymphocytes were further analyzed for fraction Fr. A (CD24^- BP1^-), Fr. B (CD24⁺BP1^-), and Fr. C (CD24⁺BP1⁺), and B220⁺CD43^- lymphocytes were further analyzed for fraction Fr. D (IgM^-IgD^-), Fr. E (IgM⁺IgD^-), and Fr. F (IgM⁺IgD⁺). (d, e) Quantification of subpopulations in B220⁺CD43⁺ lymphocytes (d) (/group) and B220⁺CD43^- lymphocytes (e) (/group). Data in (b, d, and e) were presented as .

(a)

(b)

(c)

(d)

(e)