Integrated Single-Cell and RNA Sequencing Analysis Identifies Key Immune Cell and Dendritic Cells Associated Genes Participated in Myocarditis

Figure 6

Integration analysis of monocyte cluster and hub gene reveals that DC-related Mmp12 is a key gene in myocarditis. (a) The expression of top 10 marker genes of monocyte cluster 9 in 26 clusters was displayed on the heatmap. (b) UMAP of monocytes identified in heart infiltrates was determined 3 subclusters. (c) Relative distribution of 3 monocyte subclusters in the myocarditis group and the control group. (d) The expression and distribution of the hub genes in the 26 clusters were visualized on the bubble plot. (e) The expression and distribution of Mmp12, Gpnmb, and Atp6v0d2 in the 26 clusters were visualized on the bubble plot.

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