Crosstalk between ILC2s and Th2 CD4⁺ T Cells in Lung Disease

Table 1

Crosstalk mechanism between ILC2s and CD4+T cells.

Effects of ILC2s on CD4^+T cells	Effects of CD4^+T cells on ILC2s
CD80 and CD86 on ILC2s [75]	Acting on major histocompatibility complex; class II (MHCII) expressed on ILC2s [75]
IL-13 [77, 78] and IL-9 [79] secreted by ILC2s
Regulation DCs to promote Th2 polarization [48, 80, 81]	IL-4/IL-13 secreted by CD4^+T [82]
Contact through PD-L1:PD-1 [83] and OX40L:OX40 [84]	IL-2 secreted by CD4^+T [76]
High mRNA expression of serine protease inhibitor B3 and B4 mRNA [85]	Contact through ICOSL:ICOS [86]