The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

Figure 1

Cryptolepine activates IFN-1 response in THP1-derived macrophages. The derived macrophages from the parent THP1 cells were cultured with 0.5–4 μM cryptolepine (CRYPT). IFN-α (400 IU/mL) was employed as an experimental positive control. The IFIT1 induction (a), as well as cell viability (b), was evaluated after 24 h. Data are shown as the means, from three varied experiments with each done in triplicate, and error bars represent the standard deviations. , , , and ; ns: difference not significant (one-way ANOVA and Bonferroni’s test).

(a)

(b)