Histopathological and Immunohistochemical Features of Small to Big Satellite Nevus Uncover the Nevogenesis of Large/Giant Congenital Melanocytic Nevus

Figure 1

lgCMN develops from the epidermis to the dermis. (a) IHC staining of SOX10 in the smallest satellite nevus included in this study ( μm). (b) IHC staining of SOX10 and Ki67 in nevocyte nests in serial sections ( μm). (c) i. Nevocyte nests (indicated by the arrows) in the epidermal rete ridges and few nevocytes in the dermis of small satellite nevi; ii. the nevocyte nests expanded towards the dermis (indicated by the star); iii. nevocytes and melanin were presented in the dermis of satellite nevi but were limited to the superficial dermis; iv. a large number of nests penetrated the dermis; v. large nests in the dermis; vi. dispersed nevocytes and melanin in the dermis (H&E;  μm). (d) lgCMN patients without nests in the dermis appeared to be significantly older than those with nests in the dermis ( value =0.0002).

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