Histopathological and Immunohistochemical Features of Small to Big Satellite Nevus Uncover the Nevogenesis of Large/Giant Congenital Melanocytic Nevus

Figure 6

Schematic illustration of nevogenesis (created with BioRender). The mutated melanocyte first colonizes and proliferates along the basal layer of the epidermis, after which some of the nevocytes proliferate and form nests composed of aggregated nevocytes. As the nest grows, it gradually penetrates and disperses the dermis, forming a high density of round-shaped nevocytes in the superficial dermis and a low density of spindle-shaped nevocytes in the deep dermis.