Control of Tumors by Antigen-Specific CD8⁺ T Cells through PDL1-Targeted Delivery of Antigenic Peptide

Figure 1

Generation and characterization of therapeutic chimeric proteins. (a) Schematic diagram of chimeric protein containing PDL1-scFv, Fc portion of human IgG1, furin cleavage site (RVKR), and E7 peptide (RAHYNIVTF). (b) SDS-PAGE of purified chimeric protein from Expi293F cells transfected with PD-L1-scFv-Fc and PD-L1-scFv-Fc-RE7 constructs. Arrow pointing at the bars indicating the size of PDL1-scFv-Fc and PDL1-scFv-Fc-RE7.

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