Expression Analysis of Ligand-Receptor Pairs Identifies Cell-to-Cell Crosstalk between Macrophages and Tumor Cells in Lung Adenocarcinoma

Figure 2

The ligand-receptor gene pairs identified in the autocrine network of lung adenocarcinoma tumor cells. (a) Volcano plot of the differentially expressed genes between tumor cells and normal epithelial cells. (b) The network of selected upregulated ligand-receptor gene pairs in tumor cells of lung adenocarcinoma (blue round rectangles: ligands; yellow ellipse shapes: receptors; line width is consistent with the correlation coefficient between the ligand and receptor). (c) The network of selected downregulated ligand-receptor gene pairs in tumor cells of lung adenocarcinoma (blue round rectangles: ligands; yellow ellipse shapes: receptors; line width: consistent with the correlation coefficient). (d) GSVA analysis of the Hallmark gene sets identifies significant functional pathways in lung adenocarcinoma cells (tumor cells vs. normal epithelial cells).

(a)

(b)

(c)

(d)