Expression Analysis of Ligand-Receptor Pairs Identifies Cell-to-Cell Crosstalk between Macrophages and Tumor Cells in Lung Adenocarcinoma

Figure 3

The ligand-receptor gene pairs identified in the autocrine network of macrophages. (a) Volcano plot of the differentially expressed genes between tumor-associated macrophages and nontumor-associated macrophages. (b) The network of selected upregulated ligand-receptor gene pairs in macrophages of lung adenocarcinoma (blue round rectangles: ligands; yellow ellipse shapes: receptors; line width is consistent with the correlation coefficient between the ligand and receptor). (c) The network of selected downregulated ligand-receptor gene pairs in macrophages of lung adenocarcinoma (blue round rectangles: ligands; yellow ellipse shapes: receptors; line width is consistent with the correlation coefficient between the ligand and receptor). (d) GSVA analysis of the Hallmark pathways in macrophages (tumor-associated macrophages vs. nontumor-associated macrophages).

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