Upregulation of PD-1 Expression and High sPD-L1 Levels Associated with COVID-19 Severity

Figure 2

Increased expression of PD-1 on CD14+ monocytes is associated with the duration of SARS-CoV-2 infection. Frequency of total lymphocytes (a), CD4+ CD3+ T-cells (b), CD4+ PD-1+ T-cells (c), CD8+ CD3+ T-cells (d), CD8+ PD1+ T-cells (e), CD19+ cells (f), CD19+ PD-1+ cells (g), total monocyte frequency (h), and CD14+ PD-1+ cells (i) assessed by flow cytometry in peripheral blood samples of control subjects () and patients in moderate (), severe (open symbol ), and critical (red symbol, ) clinical status. .