Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice

Figure 1

Sesamin attenuated APAP-induced acute liver injury in mice: (a) sesamin structural formula; (b) serum ALT activity; (c) serum AST activity; (d) hepatic H&E staining, black arrows indicate necrotic hepatocytes; (e) quantitative analysis of hepatic necrosis. Data were expressed as mean ± SD; sesamin group mice were oral gavage with 100 mg/kg sesamin, APAP group mice were intraperitoneally injected with 350 mg/kg APAP for 24 hr, sesamin + APAP group mice received oral gavages of sesamin 100 mg/kg at 16.5, 8.5, and 0.5 hr for three times before 350 mg/kg APAP administration (biological repeats n = 6), ^## compared with the control group, , , compared with APAP group.

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