Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice

Figure 5

Effect of sesamin on the production of proinflammatory and anti-inflammatory cytokines in the liver of mice exposed by APAP: (a) quantification of hepatic TNF-α mRNA expression; (b) quantification of hepatic IL-1β mRNA expression; (c) quantification of hepatic IL-10 mRNA expression; (d) quantification of hepatic TNF-α protein levels; (e) quantification of hepatic IL-1β protein levels; (f) quantification of hepatic IL-10 protein levels. Data were expressed as mean ± SD; sesamin group mice were oral gavage with 100 mg/kg sesamin, APAP group mice were intraperitoneally injected with 350 mg/kg APAP for 24 hr, sesamin + APAP group mice received oral gavages of sesamin 100 mg/kg at 16.5, 8.5, and 0.5 hr for three times before 350 mg/kg APAP administration (biological repeats n = 6), ^#, ^## compared with the control group, , , compared with APAP group.

(a)

(b)

(c)

(d)

(e)

(f)