Exosome Derived from Human Umbilical Cord Mesenchymal Cell Exerts Immunomodulatory Effects on B Cells from SLE Patients
Table 2
Characteristics of untreated SLE patients and HC.
Features
HC (n = 22)
SLE (n = 28)
P-value
Age (years)
30.09 ± 4.06
31.86 ± 6.64
0.253
Gender (F/M)
16/6
20/8
0.919
Clinical manifestations
Fever
0 (0.0%)
2 (7.1%)
0.201
Rashes
0 (0.0%)
6 (21.4%)
0.021
Arthritis
0 (0.0%)
7 (25%)
0.011
Serositis
0 (0.0%)
4 (14.3%)
0.065
Nephritis
0 (0.0%)
15 (53.6%)
CNS involvement
0 (0.0%)
2 (7.1%)
0.201
Cardiac involvement
0 (0.0%)
3 (10.7%)
0.113
Gastrointestinal involvement
0 (0.0%)
4 (14.3%)
0.065
Laboratory data
ANA antibody positive
0 (0.0%)
16 (57.1%)
Anti-SSA antibody positive
0 (0.0%)
11 (39.3%)
Anti-SSB antibody positive
0 (0.0%)
5 (17.9%)
Anti-SM antibody positive
0 (0.0%)
6 (21.4%)
0.002
Anti-dsDNA antibody positive
0 (0.0%)
5 (17.9%)
0.024
WBC (×109/L)
8.14 ± 1.36
6.14 ± 1.89
Hb (g/L)
136.5 ± 9.93
118.43 ± 19.56
PLT (×109/L)
239.82 ± 15.27
196.61 ± 47.20
C3 (g/L)
1.34 ± 0.12
0.43 ± 0.07
C4 (g/L)
0.32 ± 0.35
0.13 ± 0.05
24-hr urinary protein (g)
0.13 ± 0.02
3.74 ± 2.05
Data are reported as means ± SD or number and percent within parentheses. CNS, central nervous system; ANA, antinuclear antibodies; dsDNA, double-stranded DNA; WBC, white blood cells; Hb, blood hemoglobin; PLT, blood platelets; C3, complement 3; C4, complement 4. Significant differences () are shown in bold. Student’s t-test, or the χ2 test, was used as appropriate.
