SERPINB4 Promotes Keratinocyte Inflammation via p38MAPK Signaling Pathway

<div>SERPINB4 activated p38MAPK pathway in HaCaT: (a) levels of phospho-p38, p38 in HaCaT after transfection with SERPINB4 (Sh-1 or Sh-2) or vector (Sh-nc) with 10 ng/ml M5 for 12 hr analyzed by Western blot analysis, (b) levels of phospho-p38, p38 in HaCaT after transfection with overexpressing lentivirus (SER) or Control (VEC) with 2.5 ng/ml M5 for 12 hr analyzed by Western blot analysis, (c) levels of phospho-p38, p38 in HaCaT after transfection with overexpressing lentivirus (SER) or Control (VEC) with 2.5 ng/ml M5 for 12 hr before exposure to 10 <i>μ</i>M SB203580 (p38 inhibitor) analyzed by Western blot analysis, (d) mRNA expression of CXCL1, CXCL2, S100A7, CCL20, and CXCL8 examined by real-time PCR. 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Journal of Immunology Research

fig5

Figure 5

Figure 5: SERPINB4 Promotes Keratinocyte Inflammation via p38MAPK Signaling Pathway 