Immunohistochemical Features of MMP-9 and pSTAT1 in Granuloma Annulare and Sarcoidosis: A Comparative Study of 62 Cases

Figure 4

pSTAT1 expression in granuloma annulare and sarcoidosis biopsies. (a) IHC staining (upper row) and segmentation (lower row) in patients with GA (left column) and sarcoidosis (right column), . (b) Quantification of IHC staining for pSTAT1 in patients with GA and sarcoidosis. (c) pSTAT1 IHC in GA patients with mild (left panel) and massive (right panel) mucin cutis and collagen denaturation, . (d) Correlation between pSTAT1 expression and area of mucin cutis and collagen denaturation in GA; quantification of IHC staining for pSTAT1 in palisading and interstitial GA biopsies. (e) pSTAT1 IHC in sarcoidosis patients with pSTAT1 strong (left panel) and weak (right panel) staining, . (f) Correlation between pSTAT1 expression and lymphocyte density; correlation between pSTAT1 and MMP-9 expression in sarcoidosis.

(a)

(b)

(c)

(d)

(e)

(f)