Research Article
Drug Resistance of Mycobacterium tuberculosis Based on Whole-Genome Sequencing in the Yi Ethnic Group, Sichuan Province, China
Table 2
Drug resistance and gene mutation type in 116 strains.
| | Drug | Resistant strains | Mutation | | % | Type | | % |
| | RIF | 22 | 18.97 | rpoB_S450L | 4 | 18.18 | | rpoB_H445Y | 3 | 13.64 | | rpoB_D435Y | 2 | 9.09 | | rpoB_H445S | 2 | 9.09 | | rpoB_R225P; rpoB_S450L | 2 | 9.09 | | rpoB_D435V | 1 | 4.55 | | rpoB_D545E | 1 | 4.55 |
| | INH | 13 | 11.21 | rpoB_E156D | 1 | 4.55 | | rpoB_H445V | 1 | 4.55 | | rpoB_K119N | 1 | 4.55 | | rpoB_K446Q; rpoB_D545E | 1 | 4.55 | | rpoB_P280L; rpoB_L452P | 1 | 4.55 | | rpoB_S450L; rpoB_D545E | 1 | 4.55 | | rpoB_P45A; rpoB_S450L | 1 | 4.55 | | katG_S315T | 4 | 30.77 | | katG_S315N | 3 | 23.08 | | katG_frameshift | 2 | 15.38 | | inhA_S94A | 1 | 7.69 | | katG_gene_deletion | 1 | 7.69 | | katG_S315N; katG_W90stop | 1 | 7.69 | | fabG1_T-8G; ahpC_C-57 T | 1 | 7.69 | | Sm | 12 | 10.34 | rpsL_K88R | 5 | 41.67 | | rpsL_K43R | 3 | 25.00 | | rrs_C799T | 2 | 16.67 | | rrs_G888A | 1 | 8.33 | | gid_326_del_C | 1 | 8.33 | | FQs | 10 | 8.62 | gyrA_A90V | 4 | 40.00 | | gyrA_D94G | 2 | 20.00 | | gyrA_D94N | 1 | 10.00 | | gyrA_D94A | 1 | 10.00 | | gyrA_A90V; gyrA_D94A | 1 | 10.00 | | gyrB_D461N; gyrA_A90V | 1 | 10.00 | | EMB | 8 | 6.90 | embB_M306V | 3 | 37.50 | | embB_M306I | 2 | 25.00 | | embB_G406S | 1 | 12.50 | | embA_C-16G | 1 | 12.50 | | embB_M306I; embB_D354A | 1 | 12.50 | | PZA | 5 | 4.31 | pncA_D63G | 1 | 20.00 | | pncA_D49A | 1 | 20.00 | | pncA_frameshift | 1 | 20.00 | | pncA_L151S; pncA_D63G | 1 | 20.00 | | pncA_G108R; pncA_D49N | 1 | 20.00 |
| | Am | 4 | 3.45 | rrs_C1402A; rrs_G1484T | 2 | 50.00 | | rrs_C1402A | 1 | 25.00 | | rrs_A1401G | 1 | 25.00 | | Cm | 4 | 3.45 | rrs_C1402A; rrs_G1484T | 2 | 50.00 | | rrs_C1402A | 1 | 25.00 | | rrs_A1401G | 1 | 25.00 | | Km | 4 | 3.45 | rrs_C1402A; rrs_G1484T | 2 | 50.00 | | rrs_C1402A | 1 | 25.00 | | rrs_A1401G | 1 | 25.00 | | PAS | 2 | 1.72 | thyA_H75N | 1 | 50.00 | | folC_E153A | 1 | 50.00 | | BDQ | 1 | 0.86 | Rv0678_192_ins_G | 1 | 100.00 | | LZD | 0 | 0.00 | / | / | / |
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Note: RFP: rifampicin; INH: isoniazid; EMB: ethambutol; PZA: pyrazinamide; Sm: streptomycin; Am: amikacin; Cm: capreomycin; Km: kanamycin; FQs: fluoroquinolones; PAS: para-aminosalicylic acid; BDQ: bedaquiline; LZD: linezolid.
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