Protein Phosphatase 2A: Role in T Cells and Diseases

Figure 1

PP2A in Th1/Th2 paradigm. PP2A maintains a reciprocal balance between Th1 and Th2 cells. PP2A binds to the promoter and induces the expression of transcription factors Stat6 and Gata3 promoting the differentiation of Th2 cells. In contrast, PP2A inhibits the generation of Th1 cells by restraining the mTORC1 activity and subsequent Ifnγ and Tnfα gene transactivation.