Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells

Figure 1

Irradiation prevents the histopathological development of renal lesions in NZBWF1 mice. (a, b) Histopathological assessment of kidney tissue samples from paired mice 15 weeks after treatment based on hematoxylin and eosin (HE) staining (a) and periodic acid-Schiff (PAS) staining (b) (Group A). Images of i and iii, and ii and iv were from sham-irradiated and 4 Gy-irradiated mice, respectively. Images of i and ii, and iii and iv were from paired mice, respectively. Scale bars indicate 50 μm. (c) Comparison of the renal lesion grades between paired sham-irradiated and irradiated mice 15 weeks after treatment (n = 13 paired mice). (d) Renal lesion grades in sham-irradiated and irradiated mice 15 weeks after treatment (n = 13 in each group). Open and solid bars indicate sham-irradiated and four irradiated mice, respectively. Data are presented as mean ± standard error. The presents significant differences at .

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