RND3 Potentiates Proinflammatory Activation through NOTCH Signaling in Activated Macrophages

Figure 6

Schematic representation of RND3 induction and interaction with TLR4 and IFNγ receptor signaling in activated proinflammatory macrophages. RND3 is transiently induced in macrophages activated through TLR-4 and IFN-γ. Afterward RND3 potentiates NOTCH1 activation in macrophages and this process enhances the NFκB and STAT1 transcriptional activity induced by TLR-4 and IFN-γ signaling pathway, respectively, resulting in the increased expression of STAT1 and NF-κB proinflammatory genes target genes, such as Tnf-α, Irf-1, or Cxcl-10 among others.