Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma

Figure 4

Based on the 100 ns MD simulations of the CD70-CPP-TNF–TNF receptor complex, the figure shows the: (a) root-mean-square deviation (RMSD) plot of vaccine. (b) RMSD plot of receptor. (c) Root-mean-square fluctuation (RMSF) plot of the ligand (blue line) and receptor (pink line). (d) Hydrogen bonds. (e) The radius of Gyration (Rg) plot of ligand. (f) The Rg plot of receptor. (g) Solvent accessible surface area (SASA) of the vaccine construct (red line), TNF receptor (blue line), and vaccine-TNF receptor complex (black line). (h) Interaction energy plot over the simulation timescale.

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