Research Article
Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma
Table 1
Interaction similarity scores of the selected CTL epitopes in CD70 protein.
| | Protein name | Epitope | HLA-A01:01 (PDB ID:4NQV) | HLA-A02:01 (PDB ID:4UQ3) | HLA-A03:01 (PDB ID:3RL2) | HLA-A24:02 (PDB ID:5HGA) | HLA-A11:01 (PDB ID:1 × 7Q) | HLA-B07:02 (PDB ID:5EO1) | HLA-B08:01 (PDB ID:3SPV) | HLA-B27:05 (PDB ID:1OGT) | HLA-B35:01 (PDB ID:3LKN) | HLA-B51:01 (PDB ID:1E27) | Average of interaction similarity score |
| | CD70 (Homo sapiens) | CD70 (43–55) | 211 | 245.5 | 228 | 226.5 | 229 | 240 | 229.5 | 235.5 | 263.5 | 260 | 236.85 | | CD70 (70–83) | 208.7 | 265.3 | 221.2 | 242.9 | 218.5 | 216.3 | 229 | 215.9 | 219.9 | 218.1 | 225.58 | | CD70 (72–86) | 208.7 | 265.5 | 221.2 | 243.6 | 218.5 | 218.4 | 225.8 | 216.1 | 225.2 | 215.5 | 225.85 | | CD70 (99–112) | 174.8 | 209.6 | 190.1 | 248 | 187.4 | 207 | 230.3 | 190.6 | 191.7 | 194 | 202.35 | | CD70 (118–132) | 164.4 | 212.8 | 117.4 | 188.9 | 175.1 | 184.6 | 178.6 | 173.3 | 188.9 | 253 | 183.7 | | CD70 (134–147) | 162 | 216 | 180.8 | 198 | 178 | 196.7 | 187.9 | 194.2 | 236.9 | 207.6 | 195.81 | | CD70 (138–147) | 144.4 | 183.5 | 163.5 | 196 | 160.3 | 170.7 | 157.9 | 173.6 | 235 | 190 | 177.49 |
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Higher rate shows better quality of peptide-MHC interactions. |
