Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma
Table 5
MHC-I processing prediction and immunogenicity scores of CD70 CTL epitopes.
Protein name
Position
Epitope sequence
TAP transport efficiency score
Proteasomal C terminal cleavage score
Epitope identification score
immunogenicity scores
CD70 (Homo sapiens)
43–55
QAQQQLPLESLGW
1.097
0.812
0.8
−0.34715
70–83
DPRLYWQGGPALGR
1.758
0.629
0.55
0.20741
72–86
RLYWQGGPALGRSFL
2.002
0.632
0.5
0.20189
99–112
HRDGIYMVHIQVTL
1.202
0.976
0.33
0.14608
118–132
TTASRHHPTTLAVGI
1.3
0.939
0.8
0.1051
134–147
SPASRSISLLRLSF
2.39
0.871
0.431
0.37487
138–147
RSISLLRLSF
2.98
0.883
0.514
0.20217
Higher score shows better quality of TAP transport efficiency, higher score shows better quality of proteasomal cleavage, higher rates show better quality of epitope identification, higher score indicates a greater probability of eliciting an immune response.
