Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses

Table 2

Reanalysis results of association between interleukin-18 gene polymorphisms and rheumatoid arthritis.

Gene sites	Subgroup	Study number	Number of case/control	Heterogeneity (I^2, p)	OR (95% CI), p	Grading
IL-18 -607 C/A
Allele	Overall	12	6,838/5,816	86, <0.00001	0.76 (0.61, 0.93), 0.01	Weak
	Caucasian	5	2,506/1,900	91, <0.00001	0.72 (0.46, 1.12)	Nonsignificant
	Asian	5	3,926/3,068	86, <0.0001	0.73 (0.52, 1.02)	Nonsignificant
Recessive	Overall	12	3,419/2,908	80, <0.00001	0.73 (0.50, 1.06)	Nonsignificant
	Caucasian	5	1,253/950	86, <0.0001	0.73 (0.36, 1.50)	Nonsignificant
	Asian	5	1,963/1,534	79, 0.0006	0.68 (0.37, 1.24)	Nonsignificant
Dominant	Overall	12	3,419/2,908	81, <0.00001	0.67 (0.50, 0.90), 0.008	Weak
	Caucasian	5	1,253/950	86, <0.00001	0.63 (0.37, 1.07)	Nonsignificant
	Asian	5	1,963/1,534	86, <0.0001	0.64 (0.38, 1.07)	Nonsignificant
Hemozygote	Overall	12	1,744/1,389	84, <0.00001	0.57 (0.35, 0.91), 0.02	Weak
	Caucasian	5	657/445	89, <0.00001	0.55 (0.23, 1.34)	Nonsignificant
	Asian	5	1,003/781	86, <0.00001	0.53 (0.24, 1.14)	Nonsignificant
Heterozygote	Overall	12	2,658/2,271	77, <0.00001	0.71 (0.54, 0.93), 0.01	Weak
	Caucasian	5	1,070/799	78, 0.001	0.68 (0.43, 1.06)	Nonsignificant
	Asian	5	1,408/1,104	81, <0.0001	0.67 (0.40, 1.14)	Non-significant
IL-18 -137 G/C
Allele	Overall	9	3,346/3,284	88, <0.00001	0.74 (0.52, 1.05)	Nonsignificant
	Caucasian	5	2,486/1,900	93, <0.00001	0.68 (0.39, 1.17)	Nonsignificant
	Asian	2	454/536	0, 0.58	0.59 (0.40, 0.88), 0.01	Weak
Recessive	Overall	9	1,673/1,642	83, <0.00001	0.70 (0.33, 1.51)	Nonsignificant
	Caucasian	5	1,243/950	91, <0.00001	0.57 (0.20, 1.61)	Nonsignificant
	Asian	2	227/268	0, 0.33	0.48 (0.11, 2.07)	Nonsignificant
Dominant	Overall	9	1,673/1,642	74, 0.0002	0.76 (0.56, 1.04)	Nonsignificant
	Caucasian	5	1,243/950	85, <0.0001	0.73 (0.46, 1.18)	Nonsignificant
	Asian	2	227/268	0, 0.82	0.57 (0.37, 0.89), 0.01	Weak
Hemozygote	Overall	9	1,089/1,085	83, <0.00001	0.67 (0.30, 1.47)	Nonsignificant
	Caucasian	5	765/593	91, <0.00001	0.54 (0.18, 1.59)	Nonsignificant
	Asian	2	190/205	0, 0.35	0.43 (0.10, 1.86)	Nonsignificant
Heterozygote	Overall	9	1,553/1,497	8, 0.37	0.89 (0.76, 1.06)	Nonsignificant
	Caucasian	5	1,136/824	23, 0.27	0.94 (0.75, 1.17)	Nonsignificant
	Asian	2	224/260	0, 0.95	0.60 (0.38, 0.94), 0.03	Weak
IL-18 -920 C/T
Allele	Overall	2	3,746/2,182	0, 1.00	0.85 (0.76, 0.95), 0.004	Weak
Recessive	Overall	2	1,873/1,091	67, 0.08	0.29 (0.03, 3.36)	Nonsignificant
Dominant	Overall	2	1,873/1,091	0, 0.85	0.90 (0.76, 1.08)	Nonsignificant
Hemozygote	Overall	2	1,038/615	66, 0.08	0.30 (0.03, 3.35)	Nonsignificant
Heterozygote	Overall	2	1,572/837	0, 0.84	1.01 (0.84, 1.21)	Nonsignificant

Bold ORs with 95% CI indicate statistical meaning with p value less than 0.05.