Disturbances in the IgG Antibody Profile in HIV-Exposed Uninfected Infants Associated with Maternal Factors

Figure 1

Altered IgG subclass profile in HEU newborns. The plasma concentrations of the antibodies were quantified using multianalyte flow assays. Quantification of IgG1, IgG2, IgG3, and IgG4 in mothers (a–d) and newborns (e–h). Plasmatic concentrations of IgM, IgA, and IgE in mothers (i–k) and newborns (l–n). Red denotes HIV–HEU pairs, while blue represents control mother–newborn pairs. The adult control group included 71 adults, 39 in the HIV group, 69 in the HUU group, and 54 in the HEU group. Boxes indicate medians and interquartile ranges, with bars indicating percentiles 5 and 95. The sparse data points indicate observations outside these percentiles. Significant differences between groups were assessed using Mann–Whitney unpaired tests; , , and . The dotted line represents reference values reported in Schauer et al.’s [32] study.

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