Journal of Immunology Research

Immunology and the Central Nervous System


Publishing date
27 Sep 2013
Status
Published
Submission deadline
10 May 2013

Lead Editor

1Department of Biochemistry and Molecular Biology, Institute of Neuroscience and School of Medicine, Autonomous University of Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, Barcelona, Spain

2School of Food Science and Environmental Health, Dublin Institute of Technology, Dublin, Ireland

3Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA


Immunology and the Central Nervous System

Description

The function of the immune system (IS) in the central nervous system (CNS) has been elusive and challenging to unravel. CNS immunity ranges from inflammatory responses following brain injury to controlling the release of neurotransmitters, and thus, there are still new and unexpected functions to be discovered. Brain diseases, including multiple sclerosis, brain tumors, and neurodegenerative disorders such as Parkinson's or Alzheimer's diseases, display abnormal lymphocyte infiltration and activation of monocytes, macrophages, microglia, and astrocytes, which can lead to an increase in pro-inflammatory cytokines. These diseases are connected with still poorly understood inflammatory responses and immune-related processes that suggest new possibilities for understanding these diseases and developing future therapeutic approaches. The recent growth in the development of engineered antibodies and active immunization for therapeutic purposes along with the success achieved in several related clinical trials have highlighted this field of research, gaining the attention of many academic laboratories and pharmaceutical industries.

In this special issue, our main interest will be on studies investigating specific aspects of the immune response within the CNS. We take particular interest in manuscripts reporting new evidence demonstrating immune alterations in neurodegenerative disorders and brain cancer, anti-inflammatory or immunotherapy treatments that may improve disease prognosis, and basic science studies conducted in disease models illustrating mechanisms of neuroimmunology and/or the beneficial or adverse effects of drugs.

We invite investigators to contribute both original articles and review articles. Potential topics include, but are not limited to:

  • Systemic immune alterations
  • Central immune responses, such as neuroinflammation and glial cell responses
  • Innate and adaptive immune responses in the CNS
  • Brain immunosurveillance
  • Cross-talk between the systemic and central IS
  • Immunity and etiopathogenesis
  • Multiple sclerosis and autoimmune encephalopathies associated with autoantibodies
  • Brain tumor immunology and immunotherapy
  • Effects of aging on the function of the IS and age-associated brain disorders
  • Preclinical studies of immune-based therapeutics
  • Clinical studies on the role of IS and interpretation of the outcome of clinical trials
  • Epidemiological studies on the IS, such as the influence of anti-inflammatory treatments or genetic polymorphisms on inflammatory genes

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jir/icns/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 512684
  • - Editorial

Immunology and the Central Nervous System

Carlos Barcia | James Curtin | ... | Daniel Larocque
  • Special Issue
  • - Volume 2013
  • - Article ID 630602
  • - Review Article

Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes

Mikolaj Piotr Zaborowski | Slawomir Michalak
  • Special Issue
  • - Volume 2013
  • - Article ID 570731
  • - Review Article

Notch Signaling and T-Helper Cells in EAE/MS

Ribal Bassil | William Orent | Wassim Elyaman
  • Special Issue
  • - Volume 2013
  • - Article ID 812456
  • - Research Article

Immunological Demyelination Triggers Macrophage/Microglial Cells Activation without Inducing Astrogliosis

Frank Cloutier | Ilse Sears-Kraxberger | ... | Hans S. Keirstead
  • Special Issue
  • - Volume 2013
  • - Article ID 521939
  • - Research Article

Lipoic Acid Treatment after Brain Injury: Study of the Glial Reaction

Brenda Rocamonde | Sara Paradells | ... | José Miguel Soria
  • Special Issue
  • - Volume 2013
  • - Article ID 721383
  • - Research Article

BCG and BCG/DNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitis

Sofia Fernanda Gonçalves Zorzella-Pezavento | Clara Pires Fujiara Guerino | ... | Alexandrina Sartori
  • Special Issue
  • - Volume 2013
  • - Article ID 623812
  • - Review Article

Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions

Tin-Tin Win-Shwe | Hidekazu Fujimaki | ... | Naoki Kunugita
  • Special Issue
  • - Volume 2013
  • - Article ID 746068
  • - Review Article

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

Roslyn A. Taylor | Lauren H. Sansing
  • Special Issue
  • - Volume 2013
  • - Article ID 320509
  • - Research Article

IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense

Dawn Nyawira Maranga | John Maina Kagira | ... | Maina Ngotho
  • Special Issue
  • - Volume 2013
  • - Article ID 413465
  • - Review Article

Initial Immunopathogenesis of Multiple Sclerosis: Innate Immune Response

Norma Y. Hernández-Pedro | Guillermo Espinosa-Ramirez | ... | Julio Sotelo
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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