Journal of Immunology Research

The Humoral Theory of Transplantation


Status
Published

1Terasaki Foundation Laboratory, Los Angeles, USA

2Harvard Medical School, Boston, USA

3Leiden University Medical Center, Leiden, Netherlands

4Vivekananda Yoga Research Foundation, CA, USA


The Humoral Theory of Transplantation

Description

The immunological basis of rejection of donor organs by recipients is critical and clinically relevant for the very survival of the allograft and for developing strategies to improve survival of donor organs in a recipient. The immunological event that occurs in a recipient upon receiving a transplant is not a singular event but sequential event encompassing different compartments of the immune system, both cellular and humoral.

In the last century, it was fairly established that antibodies are the primary mediators of both humoral and cellular immune functions and regulation. Professor Paul Ichiro Terasaki, while working as a research fellow with Sir Peter B. Medawar, realized the importance of cellular typing in organ transplantation and, upon his return to the University of California, Los Angeles, established a pioneering tissue typing procedure. In collaboration with transplant surgeon Dr. T.E. Starzl in Denver, Dr. Terasaki proved retrospectively that tissue matching could influence kidney allograft survival and functions.

Since then, immunotechnology relevant to transplantation progressed in the area of tissue typing, with the result that one could recognize multiple arrays of major histocompatibility antigens and the antibodies and subtypes produced by the allograft recipient. Dr. Terasaki realized that antibodies bind to alloantigens on donor organs to bring about their rejection and that some of them are capable of altering cellular immune functions targeting donor organs. Based on various concepts evolved in the 20th century and early 21st century, Dr. Terasaki proposed the Humoral Theory of Transplantation in 2003 in the American Journal of Transplantation.

The purpose of this special issue is to examine current developments concerning the humoral theory of transplantation by inviting original research papers and review articles relating to the theory.

Potential topics include but are not limited to the following:

  • Humoral response to MHC antigens and non-MHC biomarkers of transplantation
  • Role of antibodies in regulating cellular immune response to organ rejection
  • Subclass of antibodies and their receptors involved in organ rejection
  • Immunosuppressive strategies and agents to prevent allograft rejection
    • Therapeutic monoclonal antibodies
    • Suppressive mechanisms: antibodies, antigen-antibody complexes, anti-idiotypic antibodies, and specific and nonspecific suppressor cells
    • Antibodies regulating T, B, and NK cells and their relevance to allograft rejection
    • Immunosuppressive drugs to prevent antibody mediated rejection
    • Therapeutic preparations of IVIg-relevance to desensitization and transplantation
    • Blood transfusions: random versus donor-specific blood transfusion
  • Humoral theory of transplantation-evidence from animal experiments

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 5935123
  • - Editorial

The Humoral Theory of Transplantation

Mepur H. Ravindranath | Junchao Cai | ... | Senthamil R. Selvan
  • Special Issue
  • - Volume 2017
  • - Article ID 5619402
  • - Review Article

Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study

Caner Süsal | Alexander Fichtner | ... | Christian Morath
  • Special Issue
  • - Volume 2017
  • - Article ID 3475926
  • - Review Article

HLA Class Ia and Ib Polyreactive Anti-HLA-E IgG2a Monoclonal Antibodies (TFL-006 and TFL-007) Suppress Anti-HLA IgG Production by CD19+ B Cells and Proliferation of CD4+ T Cells While Upregulating Tregs

Mepur H. Ravindranath
  • Special Issue
  • - Volume 2017
  • - Article ID 3406230
  • - Review Article

HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined

Nadim El-Awar | Vadim Jucaud | Anh Nguyen
  • Special Issue
  • - Volume 2017
  • - Article ID 1043836
  • - Research Article

Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation

Xiaosu Zhao | Xiangyu Zhao | ... | Yingjun Chang
  • Special Issue
  • - Volume 2017
  • - Article ID 7903471
  • - Review Article

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection

Carrie L. Butler | Nicole M. Valenzuela | ... | Elaine F. Reed
  • Special Issue
  • - Volume 2017
  • - Article ID 1747030
  • - Research Article

De Novo Donor-Specific HLA Antibodies Developing Early or Late after Transplant Are Associated with the Same Risk of Graft Damage and Loss in Nonsensitized Kidney Recipients

Michela Cioni | Arcangelo Nocera | ... | Fabrizio Ginevri
  • Special Issue
  • - Volume 2017
  • - Article ID 2748614
  • - Research Article

The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA

Vadim Jucaud
  • Special Issue
  • - Volume 2017
  • - Article ID 9130879
  • - Research Article

Computational Approaches to Facilitate Epitope-Based HLA Matching in Solid Organ Transplantation

Kirsten Geneugelijk | Jeroen Wissing | ... | Eric Spierings
  • Special Issue
  • - Volume 2017
  • - Article ID 5672523
  • - Research Article

Impact of Desensitization on Antiviral Immunity in HLA-Sensitized Kidney Transplant Recipients

Mieko Toyoda | Bong-Ha Shin | ... | Stanley C. Jordan
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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