Journal of Immunology Research

Immunity to Ocular and Genital Herpes Simplex Viruses Infections


Publishing date
18 May 2012
Status
Published
Submission deadline
18 Nov 2011

1Immunology Unit, Pathology & Clinical Laboratory Medicine, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia

2Laboratory of Cellular & Molecular Immunology, The Gavin Herbert Eye Institute, School of Medicine, UC Irvine, Hewitt Hall, 843 Health Sciences Road, Building 843, Irvine, CA 92697-4390, USA

3INSERM U1058, Département de Bactériologie-Virologie, CHRU de Montpellier, Arnaud de Villeneuve Hospital, Montpellier, France

4Department of Pathology and Molecular Medicine, Institute of Molecular Medicine and Health, MG DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8N 3Z5


Immunity to Ocular and Genital Herpes Simplex Viruses Infections

Description

Herpes simplex viruses type 1 and type 2 (HSV-1 and HSV-2) are amongst the most common human viral pathogens. While the majority of HSV seropositive individuals are asymptomatic, a nonnegligible number of symptomatic individuals are anguish from many recurrences per year and need treatments. In addition, HSV-2 was associated with increased risk of HIV infection. There is currently no approved herpes vaccine in the market that treats and/or prevents future outbreaks. The understanding of the protective immunity controlling herpes infections is critically required for the development of an efficient therapeutic vaccine. Immune cells functional impairment has been observed in acute and latent herpes infection at many levels including abnormal antigen presentation in the periphery and in the sensory ganglia, resistance of latently-infected neurons to apoptosis, unbalanced immunoregulatory, T-cell function, and deregulation of Th1/Th2/Th17 axes. In this special issue, we invite authors to submit original research and review articles highlighting the recent advances in herpes immunity and herpes immunotherapeutic approaches. We welcome papers that seek to define immunoregulatory and effector properties of T-cells and dendritic cells to provide new insights as to their potential for clinical use. We are interested in articles that explore salient aspects of protective immunity throughout HSV latency, reactivation, ocular and genital herpetic disease, and negative immunosynergy between HSV and HIV. Potential topics include, but are not limited to:

  • Innate and adaptive immunity to ocular and genital herpes infections
  • Impairment of dendritic cells and T-cells function in HSV infections
  • New animal models to study ocular and genital herpes immunity
  • Identification of new herpes antigens CD8+ and CD4+ T-cell epitopes
  • Preclinical and clinical trials with novel antigen-specific based vaccine and immunotherapeutic strategies
  • Negative immunosynergy between HSV and HIV

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 732546
  • - Editorial

Immunity to Ocular and Genital Herpes Simplex Viruses Infections

Aziz Alami Chentoufi | Lbachir BenMohamed | ... | Ali A. Ashkar
  • Special Issue
  • - Volume 2012
  • - Article ID 149135
  • - Review Article

Mucosal Herpes Immunity and Immunopathology to Ocular and Genital Herpes Simplex Virus Infections

Aziz Alami Chentoufi | Lbachir BenMohamed
  • Special Issue
  • - Volume 2012
  • - Article ID 284104
  • - Research Article

Herpes Simplex Virus-2 Glycoprotein Interaction with HVEM Influences Virus-Specific Recall Cellular Responses at the Mucosa

Sarah J. Kopp | Christopher S. Storti | William J. Muller
  • Special Issue
  • - Volume 2012
  • - Article ID 205313
  • - Research Article

Prediction and Identification of Potential Immunodominant Epitopes in Glycoproteins B, C, E, G, and I of Herpes Simplex Virus Type 2

Mingjie Pan | Xingsheng Wang | ... | Yuexi Li
  • Special Issue
  • - Volume 2012
  • - Article ID 728480
  • - Review Article

Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK

Patrick M. Stuart | Tammie L. Keadle
  • Special Issue
  • - Volume 2012
  • - Article ID 192791
  • - Research Article

HSV-1 miR-H6 Inhibits HSV-1 Replication and IL-6 Expression in Human Corneal Epithelial Cells In Vitro

Fang Duan | Jingyu Liao | ... | Kaili Wu
  • Special Issue
  • - Volume 2012
  • - Article ID 187585
  • - Review Article

Towards a Rational Design of an Asymptomatic Clinical Herpes Vaccine: The Old, the New, and the Unknown

Aziz Alami Chentoufi | Elizabeth Kritzer | ... | Lbachir BenMohamed
  • Special Issue
  • - Volume 2012
  • - Article ID 651691
  • - Research Article

Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells

Vaibhav Tiwari | Deepak Shukla
  • Special Issue
  • - Volume 2012
  • - Article ID 924619
  • - Research Article

PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection

Katie M. Bryant-Hudson | Daniel J. J. Carr
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision65 days
Acceptance to publication30 days
CiteScore3.330
Impact Factor3.404
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