Journal of Immunology Research

Recent Advances in Innate Immunity at the Epithelial Barrier


Publishing date
01 Jan 2020
Status
Closed
Submission deadline
23 Aug 2019

Lead Editor
Guest Editors

1University of Pittsburgh, Pennsylvania, USA

2Baylor College of Medicine, Texas, USA

3Sanofi, Inc., Massachusetts, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Recent Advances in Innate Immunity at the Epithelial Barrier

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Barrier tissues are considered to be the first line of defense for physically protecting the host against bacterial, fungal, viral, and parasitic pathogens. Tissues with barrier functions, such as the respiratory and intestinal tracts as well as the skin, are populated with a wide variety of innate and adaptive immune cells. Both myeloid cells (such as myeloid-derived suppressor cells) and lymphoid cells (including recently identified innate lymphoid cells) have been shown to play major roles in these tissues. Structural cells—including epithelial cells and endothelial cells—not only are the targets of immune cells but also play a role in instructing the immune activation and shaping the adaptive immune responses. The interplay between these immune cells and structural cells at the barrier sites plays an essential role not only in host defense but also in tumor surveillance and eradication, as tumors often use the same escaping mechanisms as pathogens. Recent work on host-pathogen interactions and antitumor immunity suggests that adjunctive therapy with immunomodulators could lead to improved outcomes for treating severe infections and cancer therapy though modifying the host immune responses.

This Special Issue aims to collect original research and review articles that will progress the understanding of the host-pathogen/host-tumor interactions at the barrier tissues and how pathogens or tumors breach this barrier. The Special Issue also welcomes the submission of manuscripts on developing novel therapeutic approaches targeting both the host-derived factors and the pathogens/tumors themselves.

Potential topics include but are not limited to the following:

  • Understanding the cross-talk between innate immune cells and structural cells in the context of host-pathogen/host-tumor interactions
  • Novel in vivo and in vitro models or approaches to dissect the mechanisms on tumor escape and microbial infections, including “omics” approaches
  • Characterizing drug resistance and tumor escape mechanisms for the design of combination therapeutics
  • Development of diagnostics, vaccines, or other immunoprophylactics for hospital-acquired infections and cancer prevention
  • Clinical research aimed at identifying ways to optimize the use of currently approved drugs, including novel biomarkers of the innate immunity and epithelial functions for the prediction of disease progression

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 7471380
  • - Research Article

Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors

Lei Huang | Jianning Deng | ... | Wei Jiang
  • Special Issue
  • - Volume 2019
  • - Article ID 2525984
  • - Review Article

Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis

Hui Fan | Aiyun Wang | ... | Yin Lu
  • Special Issue
  • - Volume 2019
  • - Article ID 6263249
  • - Research Article

Preoperative Risk Assessment of Lymph Node Metastasis in cT1 Lung Cancer: A Retrospective Study from Eastern China

Chengyan Zhang | Guanchao Pang | ... | Kai Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 4521231
  • - Research Article

Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response

Binfeng He | Mingdong Hu | ... | Guansong Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 1325181
  • - Review Article

Critical Roles of Balanced Innate Lymphoid Cell Subsets in Intestinal Homeostasis, Chronic Inflammation, and Cancer

Jing Wu | Xinping Lv | ... | Jingtao Chen
  • Special Issue
  • - Volume 2019
  • - Article ID 7478538
  • - Research Article

Mutated p53 Promotes the Symmetric Self-Renewal of Cisplatin-Resistant Lung Cancer Stem-Like Cells and Inhibits the Recruitment of Macrophages

Yu Xu | Zhi Xu | ... | Yuliang Liu
  • Special Issue
  • - Volume 2019
  • - Article ID 5920620
  • - Review Article

Effects of Anesthetics on Barrier Tissue Function

Fujing Wang | Yanhui Li | ... | Haichun Ma
  • Special Issue
  • - Volume 2019
  • - Article ID 7083491
  • - Research Article

Lipid-Rich Extract from Mexican Avocado Seed (Persea americana var. drymifolia) Reduces Staphylococcus aureus Internalization and Regulates Innate Immune Response in Bovine Mammary Epithelial Cells

Marisol Báez-Magaña | Alejandra Ochoa-Zarzosa | ... | Joel Edmundo López-Meza
  • Special Issue
  • - Volume 2019
  • - Article ID 2180409
  • - Review Article

Immunopathology of Airway Surface Liquid Dehydration Disease

Brandon W. Lewis | Sonika Patial | Yogesh Saini
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision65 days
Acceptance to publication30 days
CiteScore3.330
Impact Factor3.404
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