Journal of Immunology Research

Interaction Between Intestinal Microbiota, Immunology Molecular Mimicry, and AID


Publishing date
01 Sep 2021
Status
Closed
Submission deadline
30 Apr 2021

Lead Editor
Guest Editors

1The Third Xiangya Hospital, Central South University, Changsha, China

2Harvard University, Boston, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Interaction Between Intestinal Microbiota, Immunology Molecular Mimicry, and AID

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Childhood Autoimmune Diseases (AID) are of special concern owing to high incidence, poor prognosis, and high disability rate. They are characterized by tissue damage resulting from the body's immune response to its own antigens, and include Kawasaki disease (KD), Henoch-Schonlein purpura (HSP), juvenile idiopathic arthritis (JIA), autoimmune uveitis, type 1 diabetes, multiple sclerosis (MS), lupus, glaucoma, Rheumatoid Arthritis (RA), and others.

In recent years, new etiologies and mechanisms of pathogenesis have been elucidated. Nevertheless, many efforts have failed to identify potentially clear pathogenesis. As research continues, the potential relationship between the gastrointestinal tract (GIT) and the protean functions of immunity has gained more attention. The GIT microbiota, a microbial community of trillions of microorganisms consisting of more than 5,000,000 genes, plays a vital role in the stimulation of immune-related angiogenesis and the occurrence of immune-mediated disorders. Immunologists have indicated that certain pathogens can mimic and produce antigens that are similar to host autoantigens while providing inflammatory signals for activating immune cells to trigger autoimmunity and causing the body to attack itself, which is known as “molecular mimicry”. It remains to be seen where the pathogens come from in otherwise healthy individuals. Two researchers found associated deposits of antibodies that can bind to glycosylates on the bacteria's surface in heart tissue of an 11-year-old boy who died of rheumatic fever, marking the GIT microbiota as invaders. Notably, studies have also shown that the afore-mentioned antigen mimics can stimulate immune cells into immune organs such as the eye, the central nervous system (CNS), etc. Related antigens specific to T cells and B cells can cross-react with bacterial antigens in the GIT, which develops into the so-called gut-microbiota-immune system cross-talk, further inducing the occurrence and development of AID. Based on these theories, probiotic applications have been increasingly regarded as therapeutic options, including fecal transplant, immune microenvironment infiltration, etc. However, the related therapies still have limitations and lack safety testing. Undoubtedly, more well-designed studies with a larger sample size are needed to support the feasibility of these treatments, and future studies will call for an integration of metagenomic, metabolomic, and gnotobiotic tests to further advance the study and understanding of the related reactions and relationships.

The aim of this Special Issue is to gather recent studies to aid in understanding the relevance of gut microbiota-immune system cross-talk in AID and thus develop new unconventional approaches to systems biology and immunology. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

  • The predisposing factors of AID that are linked to GIT microbiota
  • Studies focusing on the primary nosogenesis of AID based on gut microbiota-immune system cross-talk
  • Factors such as epigenetics affecting the GIT microbiota further inducing the occurrence and development of AID
  • The studies of therapeutic effects to treat AID based on immune microenvironment infiltration and the internal environment of GIT microbiota
  • Single-cell profiling of immune cells involved in AID
  • The metabolites of GIT microbiota and AID
  • Identification of novel molecular microbiota-immune-targets for personalized interventions derived from omics studies

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 5571894
  • - Research Article

Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province

Bingsi Gao | Xingping Zhao | ... | Dabao Xu
  • Special Issue
  • - Volume 2021
  • - Article ID 5578958
  • - Research Article

Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles

Qiong Pan | Ya-Qian Li | ... | Qiu-Yun Tu
  • Special Issue
  • - Volume 2021
  • - Article ID 5579608
  • - Research Article

Correlation Analysis between Gut Microbiota and Metabolites in Children with Systemic Lupus Erythematosus

Min Wen | Taohua Liu | ... | Qingnan He
  • Special Issue
  • - Volume 2021
  • - Article ID 9998200
  • - Review Article

A Role for Folate in Microbiome-Linked Control of Autoimmunity

Christine Mölzer | Heather M. Wilson | ... | John V. Forrester
  • Special Issue
  • - Volume 2021
  • - Article ID 5516035
  • - Review Article

The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease

Mingxuan Chi | Kuai Ma | ... | Chi Liu
  • Special Issue
  • - Volume 2021
  • - Article ID 6679316
  • - Research Article

Ursolic Acid Regulates Intestinal Microbiota and Inflammatory Cell Infiltration to Prevent Ulcerative Colitis

Qinsong Sheng | Fei Li | ... | Kequn Chai
Journal of Immunology Research
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