Journal of Immunology Research

Immune and Inflammatory Processes in Obesity, Insulin Resistance, Diabetes, and Related Cardiometabolic Complications


Publishing date
10 Oct 2014
Status
Published
Submission deadline
30 May 2014

1University of Saskatchewan College of Medicine, Department of Physiology, Saskatoon, SK, Canada S7N 5E5

2Division of Cardiovascular Medicine, Department of Medicine, Henry Ford Heart & Vascular Institute, 2799 West Grand Boulevard, Detroit, MI 48202-2689, USA

3Department of Pharmacology, Center for Integrative Medicine, Center for Molecular Medicine (CIMMBA), University of Florence, Viale Pieraccini 6, 50139 Florence, Italy


Immune and Inflammatory Processes in Obesity, Insulin Resistance, Diabetes, and Related Cardiometabolic Complications

Description

The high prevalence of obesity and diabetes in developed and developing nations poses a great health challenge. Obesity is one of the major causes of insulin resistance and type-2 diabetes. Type-1 diabetes is primarily due to the autoimmune-mediated destruction of pancreatic beta cell leading to insulin deficiency. This is generally accompanied by alterations in lipid metabolism, enhanced hyperglycemia-mediated inflammation and oxidative stress, endothelial cell dysfunction, and apoptosis. Similarly, type-2 diabetes is characterized by elevated inflammation, glucotoxicity, lipotoxicity, and apoptosis that leads to the progressive loss of beta cells and ultimately to insulin insufficiency at later stages of the disease. Thus, in diabetes, inflammation could be triggered by hyperglycemia and/or immune response. Although insulin resistance has traditionally been associated with type-2 diabetes, mounting evidence indicates that insulin resistance in type-1 diabetes is increasing. Therefore, novel mechanistic approaches deciphering the role of inflammation in insulin resistance in type-1 and type-2 diabetes are needed. Many pathophysiological agents are implicated in insulin resistance. Although the exact natures of these factors are not completely understood, a high consensus of opinion suggests that inflammation, oxidative stress, genetic, habitual, environmental, and epigenetic factors are implicated.

Therefore, this special issue will welcome research and review papers that address a wide spectrum of inflammation-related mechanisms associated with insulin resistance, type-1 diabetes, type-2 diabetes, and related cardiometabolic complications. Potential topics include, but are not limited to:

  • Role of immune and inflammatory response in epigenetic processes implicated in type-1 and type-2 diabetes
  • Novel immune/inflammatory mechanisms of insulin resistance and dysfunctional glucose metabolism in type-1 and type-2 diabetes
  • Novel immune/inflammatory prognostic agents
  • Novel suppressors of immune/inflammatory events with potential therapeutic application
  • Role of immune/inflammatory events in macrovascular and microvascular complications of diabetic complications including atherosclerosis, cardiomyopathy, nephropathy, vasculopathy, and neuropathy

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jir/oid/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 579560
  • - Editorial

Immune and Inflammatory Processes in Obesity, Insulin Resistance, Diabetes, and Related Cardiometabolic Complications

Joseph Fomusi Ndisang | Sharad Rastogi | Alfredo Vannacci
  • Special Issue
  • - Volume 2014
  • - Article ID 240396
  • - Research Article

Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK1/2-MAPK Signaling Pathway in Diabetic Nephropathy

Luwei Zhang | Jinhang Zhang | ... | Jun Tian
  • Special Issue
  • - Volume 2014
  • - Article ID 704854
  • - Research Article

Association between the −794 (CATT)5–8  MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population

Emmanuel Valdés-Alvarado | José Francisco Muñoz-Valle | ... | Jorgé Ramón Padilla-Gutiérrez
  • Special Issue
  • - Volume 2014
  • - Article ID 309548
  • - Research Article

Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity

Karen Fjeldborg | Steen B. Pedersen | ... | Bjørn Richelsen
  • Special Issue
  • - Volume 2014
  • - Article ID 162047
  • - Clinical Study

Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus

Nailú Angélica Sinicato | Mariana Postal | ... | Simone Appenzeller
  • Special Issue
  • - Volume 2014
  • - Article ID 860703
  • - Review Article

Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation

Ana L. Guadarrama-López | Roxana Valdés-Ramos | Beatríz E. Martínez-Carrillo
  • Special Issue
  • - Volume 2014
  • - Article ID 632307
  • - Review Article

Anti-VEGF for the Management of Diabetic Macular Edema

Francisco Rosa Stefanini | Emmerson Badaró | ... | Maurício Maia
  • Special Issue
  • - Volume 2013
  • - Article ID 590190
  • - Research Article

The Role of Cytokines in the Functional Activity of Phagocytes in Blood and Colostrum of Diabetic Mothers

Danny Laura Gomes Fagundes | Eduardo Luzía França | ... | Adenilda Cristina Honorio-França
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision64 days
Acceptance to publication30 days
CiteScore3.330
Impact Factor3.404
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