Journal of Immunology Research

RNA Vaccination Therapy: Advances in an Emerging Field


Status
Published

1Center for Translational Oncology and Immunology (Tron), Mainz, Germany

2University Hospital Zurich, Zurich, Switzerland

3Duke University, North Carolina, USA

4Vrije Universiteit Brussel, Brussels, Belgium

5Novartis Vaccines & Diagnostics, Cambridge, USA


RNA Vaccination Therapy: Advances in an Emerging Field

Description

Vaccination therapy utilizing in vitro transcribed synthetic mRNA (IVT RNA) is a drug format that gained high interest in the recent years due to its fundamental characteristics and opportunities connected to its usage. IVT RNA allows engineering of RNA with defined features such as targeting of certain cell compartments, steering of protein half-life, or self-replication of mRNA. Moreover, efforts to utilize formulation technology have enabled the direct application of IVT RNA harvesting its adjuvant capacity. The development of lean and robust production and purification processes allows manufacturing of GMP RNA vaccines in short time scales and with highly competitive costs.

In the field of therapeutic cancer vaccination, IVT RNA has undergone extensive preclinical investigation, has reached late stage clinical development, and is also used for actively personalized vaccination therapy. In all studies an excellent tolerability and safety profile has been observed. Beyond cancer immunotherapy, there is growing interest in the development of antiviral mRNA based vaccines and innovative concepts adopted from viruses to achieve self-amplification.

Major challenges for mRNA vaccination therapy are identification of the optimal application route, definition of ideal formulation, investigation of immunostimulatory pathways triggered by mRNA, development of potent antigen combinations, investigation of combination therapies, and tailoring of the format for personalized immunotherapy.

We solicit high quality, original research articles, and review articles centered on research and development of mRNA based vaccination therapies in the field of cancer and infectious diseases.

Potential topics include, but are not limited to:

  • Clinical studies
  • Mechanistic studies investigating uptake, effects on RNA sensing molecules, and translation of IVT RNA
  • Studies on the utilization of RNA transfected cells for vaccination
  • Preclinical efficacy studies of RNA vaccination in animal models
  • Preclinical in vitro studies on RNA based expansion of human antigen specific T-cells
  • Studies on the induction of humoral responses by RNA vaccination
  • Studies on RNA modification or optimization for vaccination therapy
  • Studies on RNA formulation for vaccination therapy
  • Studies on combination therapies including RNA vaccination

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 9703914
  • - Editorial

RNA Vaccination Therapy: Advances in an Emerging Field

Sebastian Kreiter | Mustafa Diken | ... | Andrew Geall
  • Special Issue
  • - Volume 2016
  • - Article ID 9540975
  • - Research Article

Luciferase mRNA Transfection of Antigen Presenting Cells Permits Sensitive Nonradioactive Measurement of Cellular and Humoral Cytotoxicity

Tana A. Omokoko | Uli Luxemburger | ... | Ugur Sahin
  • Special Issue
  • - Volume 2015
  • - Article ID 595363
  • - Review Article

Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination

Mathias Vormehr | Barbara Schrörs | ... | Ugur Sahin
  • Special Issue
  • - Volume 2015
  • - Article ID 952184
  • - Research Article

Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells

Stefanie Hoyer | Kerstin F. Gerer | ... | Jan Dörrie
  • Special Issue
  • - Volume 2015
  • - Article ID 680620
  • - Review Article

Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines

Kyle K. L. Phua
  • Special Issue
  • - Volume 2015
  • - Article ID 794528
  • - Review Article

RNA-Based Vaccines in Cancer Immunotherapy

Megan A. McNamara | Smita K. Nair | Eda K. Holl
  • Special Issue
  • - Volume 2015
  • - Article ID 797421
  • - Research Article

Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice

E. Hattinger | S. Scheiblhofer | ... | R. Weiss
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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