Journal of Immunology Research

Targeting Innate Immune Cells for Immunotherapy


1Universidad de Chile, Santiago, Chile

2Pontificia Universidad Católica de Chile, Santiago, Chile

3Centro de Investigación Cooperativa en Biociencias, Bilbao, Spain

4Universidad de Antioquia, Medellín, Colombia

Targeting Innate Immune Cells for Immunotherapy


Cells of the innate immune system are key players at initiating and regulating adaptive immune responses, such as those elicited against pathogens and cancer, but also at modulating tolerance to autoantigens to prevent autoimmune diseases. While some of these cells are considered exclusively innate, as natural killer (NK) cells and innate lymphoid cells (ILCs), others are positioned at the interface of innate and adaptive immune responses, such as dendritic cells (DCs), macrophages, monocytes, and natural killer T (NKT) cells. The role of these cells in different immune responses has led to the design of targeted immunotherapies to control diseases, such as cancer, autoimmunity, and allergy, as well as potentiating immune responses against pathogens.

We invite investigators to submit original research and review articles describing the role of innate cells in immune responses against pathogens and cancer and their role in autoimmunity and allergy, as well as work describing innovative strategies to target these cells to treat different immune-related diseases.

Potential topics include, but are not limited to:

  • Role of innate immune cells in cancer and infectious diseases
  • Role of innate immune cells in autoimmunity and allergy
  • Modulation of dendritic cell maturation and phenotype
  • Dendritic cell-based immunotherapy for cancer and autoimmune diseases
  • Glycolipid targeting of NKT cells for immunotherapy
  • Emerging roles in innate lymphoid cells in immune-related diseases
  • Natural Killer cells in cancer immunity
  • Novel NKT cell-based vaccine adjuvants
  • Socioeconomic benefits of novel immune cell-targeted immunotherapies
  • Innate immune cell-targeted therapies in clinical trials


  • Special Issue
  • - Volume 2017
  • - Article ID 4271384
  • - Editorial

Targeting Innate Immune Cells for Immunotherapy

Leandro J. Carreño | Rafael Prados-Rosales | ... | Pablo A. González
  • Special Issue
  • - Volume 2016
  • - Article ID 4543861
  • - Review Article

Sipuleucel-T and Androgen Receptor-Directed Therapy for Castration-Resistant Prostate Cancer: A Meta-Analysis

Renliang Yi | Baoxin Chen | ... | Zhiheng Zhou
  • Special Issue
  • - Volume 2016
  • - Article ID 5031529
  • - Research Article

Allogeneic Antigen Composition for Preparing Universal Cancer Vaccines

Petr G. Lokhov | Elena E. Balashova
  • Special Issue
  • - Volume 2016
  • - Article ID 6078473
  • - Research Article

Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation

Ilka Knippertz | Andrea Deinzer | ... | Alexander Steinkasserer
  • Special Issue
  • - Volume 2016
  • - Article ID 9425172
  • - Research Article

Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition

Xiaocong Yu | Mark Duval | ... | Lisa A. Cavacini
  • Special Issue
  • - Volume 2016
  • - Article ID 4156456
  • - Research Article

A Fusion Protein Consisting of the Vaccine Adjuvant Monophosphoryl Lipid A and the Allergen Ovalbumin Boosts Allergen-Specific Th1, Th2, and Th17 Responses In Vitro

Stefan Schülke | Lothar Vogel | ... | Stephan Scheurer
Journal of Immunology Research
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Acceptance rate12%
Submission to final decision122 days
Acceptance to publication24 days
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Impact Factor4.1
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