Journal of Immunology Research

Tolerance and Inflammation at the Gut Mucosa


Publishing date
15 Nov 2011
Status
Published
Submission deadline
15 May 2011

1Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil

2Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA

3Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T2N 4N1

4Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan

5Institut National de la Santé et de la Recherche Médicale, U924, Université de Nice-Sophia Antipolis, 06560 Valbonne, France


Tolerance and Inflammation at the Gut Mucosa

Description

Gut mucosa is the major site of contact with antigens. In addition, it lodges the largest lymphoid tissue in the body. In physiological conditions, microbiota and dietary antigens are the natural sources of stimulation for the gut-associated lymphoid tissue (GALT) and for the immune system. Most of GALT cells are activated and a variety of proinflammatory mediators are found in this site. Local regulatory elements, however, act as a robust network that keeps gut homeostasis at check. Usually, antigen ingestion induces two noninflammatory immune responses, oral tolerance, and production of secretory IgA. However, under pathological circumstances, mucosal homeostasis is disturbed resulting in inflammatory conditions such as food hypersensitivity and inflammatory bowel diseases (IBD). The number of reported cases of food allergy and chronic IBD such as ulcerative colitis and Crohn's disease grew enormously in the past decade. Although therapies for these diseases have improved, they are still only modestly successful for long-term use and they all have many side effects. The aim of this special issue will be to shed some light into the mechanisms that keep intestinal homeostasis and to alternative therapeutic approaches for pathological conditions that emerge when theses mechanisms fail.

We invite authors to present original research articles as well as review articles that will contribute to the debate. Potential topics include, but are not limited to:

  • Oral tolerance, its mechanisms and applications
  • Role of microbiota or/and dietary antigens in the immune function
  • Cells and mediators that keep the gut homeostasis (such as induced regulatory T cells, TLRs, lipid mediators, subsets of intra-epithelial lymphocytes, and B and T cells)
  • Role of inflammatory and regulatory cytokine networks in the gut (such as TGF-β, IL-10, IL-17, IL-21, IL-22, and IL-25)
  • Role of probiotics in gut homeostasis and disease treatment
  • Food allergy
  • Coeliac disease
  • Inflammatory bowel diseases (ulcerative colitis and Crohn's disease)
  • Infections initiated at the gut mucosa (including HIV, other viruses, and bacterial and parasitic infections)
  • Intestinal cancer
  • Animal models of gut inflammatory diseases
  • Therapeutic alternatives for gut inflammatory diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 738475
  • - Editorial

Tolerance and Inflammation at the Gut Mucosa

Ana Maria C. Faria | Daniel Mucida | ... | Valerie Verhasselt
  • Special Issue
  • - Volume 2012
  • - Article ID 620278
  • - Erratum

Erratum to “Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance”

Maristela Ruberti | Luis Gustavo Romani Fernandes | ... | Wirla Maria da Silva Cunha Tamashiro
  • Special Issue
  • - Volume 2012
  • - Article ID 721085
  • - Research Article

Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model

Takeshi Yamamoto | Yuma Tsubota | ... | Makoto Kadowaki
  • Special Issue
  • - Volume 2012
  • - Article ID 208054
  • - Research Article

Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance

Maristela Ruberti | Luis Gustavo Romani Fernandes | ... | Wirla Maria da Silva Cunha Tamashiro
  • Special Issue
  • - Volume 2012
  • - Article ID 560817
  • - Research Article

New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut Mucosa

Ana Cristina Gomes-Santos | Thais Garcias Moreira | ... | Ana Maria Caetano Faria
  • Special Issue
  • - Volume 2012
  • - Article ID 279206
  • - Research Article

Persistence of Diarrheal Pathogens Is Associated with Continued Recruitment of Plasmablasts in the Circulation

Anu Kantele
  • Special Issue
  • - Volume 2012
  • - Article ID 278059
  • - Research Article

Lack of Intestinal Epithelial Atg7 Affects Paneth Cell Granule Formation but Does Not Compromise Immune Homeostasis in the Gut

Nadine Wittkopf | Claudia Günther | ... | Christoph Becker
  • Special Issue
  • - Volume 2012
  • - Article ID 396232
  • - Research Article

Early Oral Ovalbumin Exposure during Maternal Milk Feeding Prevents Spontaneous Allergic Sensitization in Allergy-Prone Rat Pups

Adaweyah El-Merhibi | Kerry Lymn | ... | Irmeli A. Penttila
  • Special Issue
  • - Volume 2012
  • - Article ID 808157
  • - Review Article

Shining a Light on Intestinal Traffic

Carola T. Murphy | Kenneth Nally | ... | Silvia Melgar
  • Special Issue
  • - Volume 2012
  • - Article ID 236564
  • - Research Article

Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice

Olívia Gonçalves de Matos | Sylvia Stella Amaral | ... | Denise Carmona Cara
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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