Journal of Immunology Research

The Role of HLA-Class Ib Molecules in Immune-Related Diseases, Tumors, and Infections 2016


Status
Published

Lead Editor

1Istituto Giannina Gaslini, Genoa, Italy

2Azienda Ospedaliera Universitaria, Ferrara, Italy

3Hôpital Saint-Louis, Paris, France

4University of Ferrara, Ferrara, Italy


The Role of HLA-Class Ib Molecules in Immune-Related Diseases, Tumors, and Infections 2016

Description

HLA-class Ib family includes HLA-E, HLA-F, HLA-G, and HLA-H molecules that, in contrast with high polymorphic HLA-class Ia molecules (HLA-A, -B, and -C), display a limited polymorphism, with a small number of alleles encoding limited functional proteins. Similar to HLA-class Ia molecules, HLA-class Ib molecules bind peptides generated from cytosolic antigens and present them to CD8+ T lymphocytes, but their main function is the regulation of immune responses, both in physiological and in pathological conditions.

HLA-G is the best characterized HLA-Ib molecule. It is expressed on fetal cytotrophoblast cells during pregnancy and abrogates maternal NK cell cytotoxicity against fetal tissues. However, HLA-G is also expressed (or released as soluble molecule) by different human tumors. HLA-G interacts with specific receptors on T and B lymphocytes, NK cells, and antigen presenting cells, inhibiting their function.

HLA-E is virtually expressed by all nucleated cells and binds peptides derived from HLA-class I molecules leader sequence. In physiological conditions, it interacts with CD94/NKG2A inhibitory receptor on NK cells, inhibiting their cytotoxicity against cells displaying normal HLA-class I molecules expression. When such molecules are downregulated (i.e., transformed or infected cells), HLA-class I-derived peptides are lower, and subsequently HLA-E expression is dampened, allowing NK cells to lyse these cells. However, different transformed cells upregulate HLA-E expression to avoid NK cell-mediated lysis.

Limited information is available regarding HLA-F function. This molecule acts as chaperone for the β2-microglobulin-free heavy chain of other HLA-class I molecules, and it is expressed on the surface of activated lymphocytes. So far, no functional HLA-H molecules encoded by HLA-H genes have been characterized. We are interested in articles that explore novel aspects of HLA-Ib molecules function.

Potential topics include, but are not limited to:

  • Expression and function of HLA-Ib molecules in pathological conditions that have not yet been investigated, including tumors, infections (virus, bacteria, and other parasites), and autoimmune/inflammatory diseases
  • Interactions between HLA-G, HLA-E, and HLA-F in pathological conditions
  • Novel mechanism of HLA-Ib molecule-mediated immune regulation
  • Possible effects of HLA-Ib molecules on cells that are crucial in pathological settings (i.e., endothelial cells during angiogenesis)
  • Presence of soluble HLA-Ib molecules in biological fluids during disease and their clinical relevance
  • HLA-Ib molecules expression and/or secretion in novel immune-regulatory cell subsets
  • Potential extraimmunological roles of HLA-Ib molecules

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2309574
  • - Editorial

The Role of HLA-Class Ib Molecules in Immune-Related Diseases, Tumors, and Infections 2016

Roberta Rizzo | Enrico Fainardi | ... | Fabio Morandi
  • Special Issue
  • - Volume 2016
  • - Article ID 6829283
  • - Review Article

The Pathophysiological Impact of HLA Class Ia and HLA-G Expression and Regulatory T Cells in Malignant Melanoma: A Review

Lasse Lindholm Johansen | Jørgen Lock-Andersen | Thomas Vauvert F. Hviid
  • Special Issue
  • - Volume 2016
  • - Article ID 8417190
  • - Research Article

Upregulation of Soluble HLA-G in Chronic Left Ventricular Systolic Dysfunction

Line Lisbeth Olesen | Thomas Vauvert F. Hviid
  • Special Issue
  • - Volume 2016
  • - Article ID 3890306
  • - Research Article

Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection

Roberta Rizzo | Liliana Gabrielli | ... | Tiziana Lazzarotto
  • Special Issue
  • - Volume 2016
  • - Article ID 2695396
  • - Review Article

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

Simone A. Joosten | Lucy C. Sullivan | Tom H. M. Ottenhoff
  • Special Issue
  • - Volume 2016
  • - Article ID 4326495
  • - Review Article

Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Fabio Morandi | Roberta Rizzo | ... | Vito Pistoia
  • Special Issue
  • - Volume 2016
  • - Article ID 7465741
  • - Research Article

Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma Patients

Fabio Morandi | Sarah Pozzi | ... | Maria Valeria Corrias
  • Special Issue
  • - Volume 2016
  • - Article ID 1910852
  • - Clinical Study

HLA-01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence

Julie Di Cristofaro | Mathieu Pelardy | ... | Christophe Picard
  • Special Issue
  • - Volume 2016
  • - Article ID 1343760
  • - Research Article

Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population

Yue-miao Zhang | Xu-jie Zhou | ... | Hong Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 6865758
  • - Review Article

Immunoregulatory Role of HLA-G in Allergic Diseases

Giuseppe Murdaca | Paola Contini | ... | Francesco Puppo
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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