Journal of Immunology Research

Genetic Factors of Autoimmune Diseases


Publishing date
18 Dec 2015
Status
Published
Submission deadline
31 Jul 2015

1Sapienza Università di Roma, Roma, Italy

2Tel Aviv University, Ramat Aviv, Israel


Genetic Factors of Autoimmune Diseases

Description

As widely demonstrated, autoimmune diseases are characterized by a multifactorial pathogenesis, in which genetic and environmental factors interact in determining disease development. Data identifying a higher concordance ratio between monozygotic twins compared to dizygotic twins or siblings have confirmed the role of genetic factors in patients affected by autoimmune diseases. To date, thanks to genomewide association studies, several genetic loci have been identified as associated with disease susceptibility. The identification of the same genetic modifications in different autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, suggests a shared immune pathogenesis. The genetic polymorphisms could influence not only the susceptibility, but also the disease phenotype, as demonstrated by the association of different loci with specific clinical manifestations or outcomes, such as response to treatment.

The proteins encoded by the genes associated with autoimmune diseases development are involved in several mechanisms participating to inflammatory process, such as antigen presentation, type I interferon, Toll-like receptor and NF-κB signaling, B- and T-cell function, apoptosis, and clearance of cellular debris and immune complexes. The genetic polymorphisms could determine modifications of these proteins, in terms of production rate and function, with possible changes in the related processes.

To date, more than 200 genetic loci have been associated with one or more disorders. Further studies are needed to better understand the implications of these associations in the susceptibility and phenotype of autoimmune diseases.

We invite investigators to contribute with original research articles as well as review articles that will stimulate the continuing efforts to better understand the genetic factors involved in the autoimmune diseases.

Potential topics include, but are not limited to:

  • Role of genetic factors in determining disease susceptibility
  • Role of genetic factors as markers of disease outcome in terms of chronic damage development and response to treatment

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 3476023
  • - Editorial

Genetic Factors of Autoimmune Diseases

Fulvia Ceccarelli | Nancy Agmon-Levin | Carlo Perricone
  • Special Issue
  • - Volume 2015
  • - Article ID 745647
  • - Review Article

Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype

Fulvia Ceccarelli | Carlo Perricone | ... | Fabrizio Conti
  • Special Issue
  • - Volume 2015
  • - Article ID 572353
  • - Research Article

Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome

John Castiblanco | Juan Camilo Sarmiento-Monroy | ... | Juan-Manuel Anaya
  • Special Issue
  • - Volume 2015
  • - Article ID 679813
  • - Research Article

Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes

Léa Campos de Oliveira | Anna Carla Goldberg | ... | Gilda Porta
  • Special Issue
  • - Volume 2015
  • - Article ID 174062
  • - Research Article

Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases

Lindner Ewald | Langner-Wegscheider Beate | ... | El-Shabrawi Yosuf
  • Special Issue
  • - Volume 2015
  • - Article ID 602154
  • - Research Article

The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus

Hun-Soo Kim | Eun-Heui Jin | ... | Soo-Cheon Chae
  • Special Issue
  • - Volume 2015
  • - Article ID 101879
  • - Research Article

Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis

Rocío Prieto-Pérez | Guillermo Solano-López | ... | Francisco Abad-Santos
  • Special Issue
  • - Volume 2015
  • - Article ID 948723
  • - Research Article

The Protective Role of HLA-DRB113 in Autoimmune Diseases

Andreia Bettencourt | Cláudia Carvalho | ... | Berta Martins da Silva
  • Special Issue
  • - Volume 2015
  • - Article ID 906086
  • - Research Article

Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus

Qian Guo | Xuyong Chen | ... | Yin Su
  • Special Issue
  • - Volume 2015
  • - Article ID 754825
  • - Review Article

Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis

Adrianos Nezos | Clio P. Mavragani
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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