Inflammation is a normal physiological defense against pathogen infection and tissue damage and quickly ends under normal circumstances. However, in many chronic conditions, the inflammatory response continues and leads to significant tissue/organ damage. Recently, increasing evidences show that the abnormal inflammatory response is closely associated with many chronic diseases, especially in autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and diabetes. Although the importance of inflammatory dysregulation in chronic illnesses has been revealed in recent years, the pathogenesis of inflammation dysfunction in the autoimmune diseases remains a complex problem. Knowledge of the mechanism of inflammation regulation will lead to significant clinical benefit for the autoimmune disease. In this special issue, we invite researchers to contribute with original research articles as well as review articles that will stimulate the continuing efforts to understand the regulation of inflammation in the pathology and the treatment of autoimmune diseases. We are particularly interested in articles describing the novel mechanism, new treatment strategies, clinical studies, advances in genetics and molecular diagnostics, and inflammatory dysregulation in autoimmune diseases.

Potential topics include but are not limited to the following:

• Clinical immunology in autoimmune diseases
• Inflammatory markers in the diagnosis of autoimmune diseases
• Role of different immune cells in modulating inflammatory response
• Anti-inflammatory agents in autoimmune diseases
• Immunotherapy in autoimmune diseases