Journal of Immunology Research

Differentiation and Function of T Cell Subsets in Infectious Diseases


Publishing date
01 Aug 2018
Status
Published
Submission deadline
13 Apr 2018

Lead Editor

1University of Texas Medical Branch, Galveston, USA

2Nanjing Medical University, Nanjing, China

3Nantong University, Nantong, China


Differentiation and Function of T Cell Subsets in Infectious Diseases

Description

Infectious diseases remain a public health problem in the world, regardless of the continued effort at control. Fresh outbreak of pathogens, such as Ebola virus and ZIKV, is a serious global threat. T cell immunity is a protective component of the host against the infection and is a helper for antibody production in vaccination strategy. The progress of T cell research has greatly accelerated since the T helper (Th) cell heterogeneity was discovered two decades ago. Th1 and Th2 cells are critical for the immunity against intracellular and extracellular infection, respectively. Several novel Th cell subsets, including regulatory T (Treg) cells, Th17, Th22, Th9, and T follicular cells, were found in the recent years in different disease models and they play an essential role for the development and outcome of diseases. Despite the adaptive T cells, there are some unconventional T cells, such as γδ T cells and NKT cells, which are defined as different subpopulations (e.g. IFN-γ+γδ T cells vs. γδ 17 T cells and IFN-γ+ NKT cells vs. NKT17 cells) based on the cytokine production. These innate-like T cells rapidly respond to pathogens and display effector functions without undergoing extensive clonal expansion. However, how does T cell get a response to various pathogens and differentiate to proper effector subsets is still not well elucidated. Therefore, future work is necessary to understand T cells differentiation and function in infectious diseases, as well as their underlying mechanisms.

Our goal of this special issue is to publish high-quality original research and review articles addressing T cell differentiation and function in infectious diseases. A particular interest of this series will be given to articles related to the life-threatening infectious diseases lacking vaccine and therapeutic treatment.

Potential topics include but are not limited to the following:

  • Novel T cell subsets in lymphoid organs and resident tissues during infection
  • Effector and memory T cell differentiation
  • Key factors that drive the unique T cell differentiation
  • Interplay of T cells with antigen-presenting cells and cytokines
  • Regulation of T cell responses by parenchymal/stromal cells
  • Role of T cell subsets in determining the disease outcome
  • T cell-based immunotherapy
  • Differentiation of unconventional T cell subpopulations triggered by unique pathogens
  • Impact of unconventional T cells for the early pathogen control and the following adaptive immunity

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 3439025
  • - Editorial

Differentiation and Function of T Cell Subsets in Infectious Diseases

Yuejin Liang | Xiaojun Chen | ... | Fengliang Liu
  • Special Issue
  • - Volume 2018
  • - Article ID 7519856
  • - Research Article

TLR3 Modulates the Response of NK Cells against Schistosoma japonicum

Jiale Qu | Lu Li | ... | Jun Huang
  • Special Issue
  • - Volume 2018
  • - Article ID 6398078
  • - Research Article

PPAR-γ Agonist Alleviates Liver and Spleen Pathology via Inducing Treg Cells during Schistosoma japonicum Infection

Yuxiao Zhu | Yangyue Ni | ... | Minjun Ji
  • Special Issue
  • - Volume 2018
  • - Article ID 5081634
  • - Review Article

Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application

Yueshui Zhao | Ling Lin | ... | Jing Shen
  • Special Issue
  • - Volume 2018
  • - Article ID 6989717
  • - Research Article

Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People

Yu Yang | Peng-Lei Xiao | ... | Yi-Biao Zhou
  • Special Issue
  • - Volume 2018
  • - Article ID 1467538
  • - Review Article

The Regulation of Inflammation by Innate and Adaptive Lymphocytes

David Alex Cronkite | Tara M. Strutt
  • Special Issue
  • - Volume 2018
  • - Article ID 2563563
  • - Research Article

Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C

Roberta C. Araújo | Fabricio C. Dias | ... | Ana L. C. Martinelli
  • Special Issue
  • - Volume 2018
  • - Article ID 8439813
  • - Review Article

Meta-Analysis of the Changes of Peripheral Blood T Cell Subsets in Patients with Brucellosis

Rongjiong Zheng | Songsong Xie | ... | Kai Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 6212410
  • - Research Article

Aberrant Peripheral Immune Function in a Good Syndrome Patient

Xian Chen | Jie-xin Zhang | ... | Fang Wang
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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