Journal of Immunology Research

Immunology of Vascularized Composite Allografts


Publishing date
21 Sep 2012
Status
Published
Submission deadline
04 May 2012

1Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

2Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA


Immunology of Vascularized Composite Allografts

Description

Over the past decade, transplantation of vascularized composite allografts (VCAs) such as hand and face transplants has become a clinical reality and a vivid treatment option for those patients in need suffering from complex tissue injuries of defects not amenable to conventional reconstruction. Despite the fact that early and intermediate functional outcomes are highly encouraging rejection, the need for chronic immunosuppressive treatment continues to be the bane of VCA preventing broader clinical application. Therefore, a thorough understanding of the immunogenicity and the basic mechanisms of an alloimmune response in VCA is a key to establish novel protocols for immunomodulation and tolerance induction after VCA without the need for long-term immunosuppression and hence favoring the delicate balance of risks and benefits for such non-life-saving types of transplants.

We invite investigators to contribute original research as well as review articles that will stimulate the continuing efforts to understand the unique immunological features of vascularized composite allografts as well as their individual components, the immunological differences compared to solid organ transplants, the molecular mechanisms and underlying pathology of skin rejection, and the development of novel strategies to avoid rejection and induce tolerance. Potential topics include, but are not limited to:

  • Research tools and animal models to study VCA immunology
  • Unique immunological features of VCA as compared to solid organ transplants
  • Advances in diagnosing skin rejection and immune monitoring
  • Tolerance protocols for VCA
  • Role of vascularized bone marrow and immunoregulatory stem cells
  • The influence of skin-specific antigen-presenting cells on VCA immunogenicity
  • Mechanisms of cellular- and antibody-mediated immune responses in acute and chronic rejection of VCA

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 689071
  • - Editorial

Immunology of Vascularized Composite Allografts

Gerald Brandacher | David H. Sachs | Angus W. Thomson
  • Special Issue
  • - Volume 2013
  • - Article ID 831410
  • - Review Article

Chimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts: Cleveland Clinic Research Experience

Maria Siemionow | Aleksandra Klimczak
  • Special Issue
  • - Volume 2013
  • - Article ID 483856
  • - Research Article

Heart Allograft Tolerance Induced and Maintained by Vascularized Hind-Limb Transplant in Rats

Quan Liu | Yong Wang | ... | Xin Xiao Zheng
  • Special Issue
  • - Volume 2013
  • - Article ID 495212
  • - Review Article

Site-Specific Immunosuppression in Vascularized Composite Allotransplantation: Prospects and Potential

Jonas T. Schnider | Matthias Weinstock | ... | Vijay S. Gorantla
  • Special Issue
  • - Volume 2013
  • - Article ID 402980
  • - Review Article

Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation

Ravi Starzl | Gerald Brandacher | ... | Xin Xiao Zheng
  • Special Issue
  • - Volume 2012
  • - Article ID 863264
  • - Review Article

Tolerance Induction Strategies in Vascularized Composite Allotransplantation: Mixed Chimerism and Novel Developments

David A. Leonard | Duncan A. McGrouther | ... | Curtis L. Cetrulo
  • Special Issue
  • - Volume 2012
  • - Article ID 704063
  • - Research Article

Vascularized Composite Allograft Rejection Is Delayed by Intrajejunal Treatment with Donor Splenocytes without Concomitant Immunosuppressants

Christopher Glenn Wallace | Chia-Hung Yen | ... | Fu-Chan Wei
  • Special Issue
  • - Volume 2012
  • - Article ID 854846
  • - Review Article

Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation

Yur-Ren Kuo | Chien-Chang Chen | ... | Chao-Long Chen
  • Special Issue
  • - Volume 2012
  • - Article ID 438078
  • - Review Article

The Need for Inducing Tolerance in Vascularized Composite Allotransplantation

Kadiyala V. Ravindra | Hong Xu | ... | Suzanne T. Ildstad
  • Special Issue
  • - Volume 2012
  • - Article ID 107901
  • - Review Article

Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts

Wei-Chao Huang | Jeng-Yee Lin | ... | Shuen-Kuei Liao
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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