Journal of Immunology Research

Serum Autoantibodies: From Identification to Clinical Relevance


Publishing date
22 Feb 2013
Status
Published
Submission deadline
05 Oct 2012

1Division of Rheumatology, Allergy and Clinical Immunology, University of California, Health Science Drive, Davis, CA 95616, USA

2Experimental Laboratory Immunology, Catholic University Leuven, Leuven, Belgium

3Division of Transplantation Immunology and Mucosal Biology, Institute of Liver Studies, King's College London, London, UK


Serum Autoantibodies: From Identification to Clinical Relevance

Description

The last few years, major developments have been made in the field of the research on autoantibodies. Several new autoantibody specificities have been described, and some of those have been linked to diseases considered not to be autoimmune in nature. The diagnostic value, clinical utility, and pathogenic significance of autoantibodies are the focus of ongoing research. Autoantibodies and their respective epitopes have been studied as biomarkers for disease progression and severity. New assays for autoantibody detection have been developed. Automated ELISA and digitalized automated immunoflourescence techniques promise fast and efficient interpretation of autoantibody testing. The pros and cons of the autoantibody immunoassays have been extensively discussed.

Cutting-edge technologies such as autoantigen microarrays, peptidomics, and immunomics have also been used to identify clinically relevant autoantigens. The pathogenic effects of some autoantibodies and their role in the induction of tissue injury are the focus of intensive research. Gender, genetic, epigenetic, and environmental factors are likely involved in the development of autoantibodies. The exact mechanisms that cause the induction of autoantibodies and overt autoimmune disease become clearer. The fine balance of the cytokine milieu and other proinflammatory and anti-inflammatory factors that facilitate the induction of humoral responses received special attention.

We are interested in gaining insight into the clinical utility and pathogenic significance of autoantibodies. We encourage authors to submit original papers and review articles on all fields of autoantibodies. Potential topics include, but are not limited to:

  • Novel cutting-edge technologies for the identification of autoantigens
  • Autoantibody testing: from academia and industry to the routine laboratory
  • Diagnostic, clinical, and prognostic significance of autoantibodies
  • Performance and technical characteristics of conventional and novel immunoassays for autoantibody testing
  • Peptides and purified and recombinant antigens as antigenic substrates
  • Microbial/host interactions facilitating the development of autoantibodies
  • Unique properties of autoantibodies and their relevance to disease
  • Interplay between autoantibodies, the immune system, and host factors
  • Genetic, epigenetic, and environmental factors influencing autoantibody production

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 382069
  • - Editorial

Serum Autoantibodies: From Identification to Clinical Relevance

Pietro Invernizzi | Xavier Bossuyt | Dimitrios P. Bogdanos
  • Special Issue
  • - Volume 2013
  • - Article ID 474028
  • - Clinical Study

Higher Levels of Autoantibodies Targeting Mutated Citrullinated Vimentin in Patients with Psoriatic Arthritis Than in Patients with Psoriasis Vulgaris

Szandra Dalmády | Mária Kiss | ... | Rolland Gyulai
  • Special Issue
  • - Volume 2013
  • - Article ID 703759
  • - Research Article

Clinical Phenotypes of Patients with Anti-DFS70/LEDGF Antibodies in a Routine ANA Referral Cohort

Makoto Miyara | Roger Albesa | ... | Michael Mahler
  • Special Issue
  • - Volume 2013
  • - Article ID 297678
  • - Research Article

Detection and Analysis of Autoantigens Targeted by Autoantibodies in Immunorelated Pancytopenia

Hui Liu | Rong Fu | ... | Zonghong Shao
  • Special Issue
  • - Volume 2013
  • - Article ID 637513
  • - Research Article

Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion

Alexandros Daponte | Efthimios Deligeoroglou | ... | Ioannis E. Messinis
  • Special Issue
  • - Volume 2013
  • - Article ID 572815
  • - Research Article

Development of a Recombinant Cell-Based Indirect Immunofluorescence Assay for the Determination of Autoantibodies against Soluble Liver Antigen in Autoimmune Hepatitis

Christiane Radzimski | Christian Probst | ... | Lars Komorowski
  • Special Issue
  • - Volume 2013
  • - Article ID 453058
  • - Review Article

An Innovative Method to Identify Autoantigens Expressed on the Endothelial Cell Surface: Serological Identification System for Autoantigens Using a Retroviral Vector and Flow Cytometry (SARF)

Tsuyoshi Shirai | Hiroshi Fujii | ... | Hideo Harigae
  • Special Issue
  • - Volume 2012
  • - Article ID 370107
  • - Research Article

BPI-ANCA and Long-Term Prognosis among 46 Adult CF Patients: A Prospective 10-Year Follow-Up Study

Ulrika Lindberg | Malin Carlsson | ... | Mårten Segelmark
  • Special Issue
  • - Volume 2012
  • - Article ID 369546
  • - Review Article

Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis

Lilla Mihályi | Mária Kiss | ... | Sándor Husz
  • Special Issue
  • - Volume 2012
  • - Article ID 432176
  • - Research Article

Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSA/Ro and Anti-SSB/La Antibodies: A Magnetocardiography Study

Annette Wacker-Gußmann | Henrike Paulsen | ... | Hubert Preissl
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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