Journal of Immunology Research

Roles of Zinc and Zinc Mediators in Immunity

Publishing date
01 Mar 2019
Submission deadline
09 Nov 2018

Lead Editor

1Deutsches Rheuma-Forschungszentrum, Berlin, Germany

2Wayne State University School of Medicine, Detroit, USA

3Tokushima Bunri University, Tokushima, Japan

This issue is now closed for submissions.

Roles of Zinc and Zinc Mediators in Immunity

This issue is now closed for submissions.


Zinc (Zn) is an essential micronutrient for basic cellular activities such as cell growth, differentiation, and survival. Although it is well-known that Zn regulates a great number of protein functions including enzymes and transcription factors as a structural and/or catalytic component, the growing evidences in last decades have changed our view of this essential trace element and brought new paradigm that Zn dynamically acts as a signaling molecule through Zn mediators such as Zn transporters, channels, and metallothioneins. These functions of Zn have been recognized as Zn signaling, which facilitates the transduction of a variety of signaling cascades in response to extracellular stimuli, and thus its imbalance can harm human health. Among the multifaceted effects of Zn deficiency, the hallmark symptom is immunodeficiency, accompanied with thymic atrophy, lymphopenia, and severe depressions of innate and adaptive immune responses, resulting in a high susceptibility to infections. However, the precise physiological mechanisms of the Zn-mediated regulation for the immune system have been still enigmatic.

In the proposed special issue, we will invite authors to submit the form of original research articles and reviews that address the roles of Zn and Zn mediators to shape immune system.

Potential topics include but are not limited to the following:

  • Roles of Zn and Zn mediators in the following:
  • Immune cell development
  • Immune cell homeostasis
  • Innate immune response
  • Adaptive immune response
  • Immune cell signaling
  • Inflammation
  • Allergy
  • Infectious diseases
  • Autoimmune diseases
  • Immune memory
  • Immune evasion


  • Special Issue
  • - Volume 2020
  • - Article ID 9207279
  • - Review Article

Lessons Learned from Experimental Human Model of Zinc Deficiency

Ananda S. Prasad
  • Special Issue
  • - Volume 2019
  • - Article ID 8396878
  • - Review Article

Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases

Wakana Ohashi | Toshiyuki Fukada
  • Special Issue
  • - Volume 2018
  • - Article ID 5404093
  • - Review Article

Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis

Youichi Ogawa | Manao Kinoshita | ... | Tatsuyoshi Kawamura
  • Special Issue
  • - Volume 2018
  • - Article ID 6872621
  • - Review Article

The Role of Zinc and Zinc Homeostasis in Macrophage Function

Hong Gao | Wei Dai | ... | Fudi Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 5749120
  • - Review Article

Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses

Keigo Nishida | Ryota Uchida
  • Special Issue
  • - Volume 2018
  • - Article ID 4315140
  • - Review Article

Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection

Muna Sapkota | Daren L. Knoell
  • Special Issue
  • - Volume 2018
  • - Article ID 9365747
  • - Review Article

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells

Bum-Ho Bin | Juyeon Seo | Sung Tae Kim
  • Special Issue
  • - Volume 2018
  • - Article ID 5982169
  • - Research Article

Combined Treatment with Zinc Aspartate and Intravenous Immunoglobulins (IVIGs) Ameliorates Experimental Autoimmune Encephalomyelitis (EAE)

Diana Straubel | Anja Thielitz | ... | Dirk Reinhold
Journal of Immunology Research
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