Journal of Immunology Research

New Insights for Immune-Based Diagnosis and Therapy for Infectious Diseases


Status
Published

1University of Georgia, Athens, USA

2Università Vita-Salute San Raffaele, Milan, Italy

3Technische Universität München, Munich, Germany

4Invisible Sentinel, Philadelphia, USA


New Insights for Immune-Based Diagnosis and Therapy for Infectious Diseases

Description

The role of the immune response as marker as well as therapeutic tool for the diagnosis and treatment of infectious diseases, is well ascertained and described; however, these concepts are continually evolving.

In the diagnostic field, the research of a specific humoral immune response has been used from a long time. In fact, the seropositivity is considered as an important key for the determination of an occurring infection. Recently, in addition to the classical investigation on the presence or absence of antibodies directed against specific antigens, the titer of specific antibodies, defined as index, is gaining importance as a prognostic marker for certain infectious diseases, for example, the introduction of the JCPyV-seropositivity, defined as the presence of specific anti-JCPyV antibodies, in the stratification of multiple sclerosis patients for the risk to develop progressive multifocal leukoencephalopathy.

The immune response is the key element to resolve an infection. For this reason, a therapeutic and a prophylactic strategy for infectious diseases is usually based on immune-based approaches. In particular, prophylactic strategies are principally focused on the stimulation of a specific immune response against the pathogen, that is, the active immunization. On the other hand, immunotherapeutic strategies are based on the concept of a passive immunization. In this case, immunoglobulins obtained from sera of immune individuals or by the cloning of recombinant antibodies (usually, antigen-specific monoclonal antibodies) are injected to protect a susceptible or infected host. In this regard, very recently, a cocktail of monoclonal antibodies is being considered as a possible treatment of Ebola virus infections.

Recently, in the context of a passive immunization, also the infusions of antigen-specific or engineered T cells, as an alternative treatment for infectious diseases, are being considered. As an example, chimeric antigen receptor- (CAR-) engineered T cells are increasingly gaining potential application also for the elimination of difficult-to-eradicate pathogens. In this regard, in the last few years, several CARs directed against different infectious agents, such as HIV, CMV, HBV, HCV, and A. fumigatus, have been described.

The purpose of this special issue is to publish high quality research paper and review articles that underline the use of immune-based approaches for the diagnosis and therapy of infectious diseases. Original, high quality contributions that are not yet published or that are not under review by other journals or peer-reviewed conferences are evaluated.

Potential topics include but are not limited to the following:

  • Immune-based diagnostic tools for infectious diseases
  • New immune-based approaches as prognostic markers for infectious diseases
  • Immunotherapeutic approaches against infectious diseases
  • Anti-infective monoclonal antibodies and their engineering
  • New prophylactic approaches against infectious diseases
  • Adoptive T cell therapy for infectious diseases
  • Engineered and redirected T cells for the treatment of infectious diseases

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 6760830
  • - Review Article

An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction

Lenka Potocnakova | Mangesh Bhide | Lucia Borszekova Pulzova
  • Special Issue
  • - Volume 2016
  • - Article ID 8374328
  • - Research Article

Altered Intracellular ATP Production by Activated CD4+ T-Cells in Very Preterm Infants

Giulia Aquilano | Maria Grazia Capretti | ... | Tiziana Lazzarotto
  • Special Issue
  • - Volume 2016
  • - Article ID 9384813
  • - Review Article

Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission

Giulia Freer | Paola Quaranta | Mauro Pistello
  • Special Issue
  • - Volume 2016
  • - Article ID 1412840
  • - Review Article

State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization

Cecilia Trucchi | Andrea Orsi | ... | Filippo Ansaldi
  • Special Issue
  • - Volume 2016
  • - Article ID 4396368
  • - Review Article

The CXCL10/CXCR3 Axis and Cardiac Inflammation: Implications for Immunotherapy to Treat Infectious and Noninfectious Diseases of the Heart

Raffaele Altara | Ziad Mallat | ... | Fouad A. Zouein
  • Special Issue
  • - Volume 2016
  • - Article ID 3530752
  • - Research Article

Delta Procalcitonin Is a Better Indicator of Infection Than Absolute Procalcitonin Values in Critically Ill Patients: A Prospective Observational Study

Domonkos Trásy | Krisztián Tánczos | ... | Zsolt Molnár
  • Special Issue
  • - Volume 2016
  • - Article ID 5457010
  • - Research Article

In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity

Gianandrea Guidetti | Alessandro Di Cerbo | ... | Giuseppe Terrazzano
Journal of Immunology Research
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Acceptance rate12%
Submission to final decision122 days
Acceptance to publication24 days
CiteScore6.000
Journal Citation Indicator0.560
Impact Factor4.1
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