Journal of Immunology Research

Neutrophils: Their Role in Innate and Adaptive Immunity


Status
Published

1Universidad Nacional Autónoma de México, Mexico City, Mexico

2University of Geneva, Geneva, Switzerland

3University of California, San Francisco, USA


Neutrophils: Their Role in Innate and Adaptive Immunity

Description

Neutrophils are the most abundant leukocytes in the blood and constitute the first line of host defense against numerous infectious pathogens, including bacteria, fungi, protozoa, and large parasites. Neutrophils migrate to sites of inflammation and infection where they recognize and phagocytose invading microorganisms in order to kill them via different cytotoxic mechanisms. These include the production of reactive oxygen species, microbicidal substances stored in granules, and the release of their nuclear material in the form of neutrophil extracellular traps.

In recent years, it has become evident that neutrophils not only have a fundamental role in the acute phase of inflammation when they actively eliminate pathogens, but also are capable of modifying the overall immune response. Neutrophils can do this by exchanging information with macrophages, dendritic cells, and other cells of the adaptive immune system through either soluble mediators or direct cell-cell contact. In addition, neutrophils are being recognized as important players in cancer and atherosclerosis, as these cells can infiltrate tumors and the atherosclerotic plaque. Thus, neutrophils can have an influence on tumor progression and inflammation leading to various stages of atherosclerosis. It is then important to understand the role of neutrophils in these disorders in order to be able to regulate their function to alleviate these health problems.

The purpose of this special issue is to publish high-quality original research papers as well as review articles addressing recent issues on the role of neutrophils in shaping the immune response and the consequences this may have on important health issues such as resolution of inflammation, autoimmunity, and cancer.

Potential topics include, but are not limited to:

  • Phagocytosis
  • Neutrophil extracellular traps
  • Signal transduction pathways regulating neutrophil activation
  • Neutrophil homeostasis
  • Resolution of inflammation
  • Neutrophils in atherosclerosis
  • Neutrophils in cancer
  • Role of neutrophils against larger parasites such as Toxoplasma and Leishmania
  • Regulation of neutrophil function
  • Neutrophils as therapeutic targets

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 120348
  • - Research Article

fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils

María A. Hidalgo | María D. Carretta | ... | Rafael A. Burgos
  • Special Issue
  • - Volume 2015
  • - Article ID 250456
  • - Research Article

CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a

Rachel Vaivoda | Christine Vaine | ... | Peter Christmas
  • Special Issue
  • - Volume 2015
  • - Article ID 235170
  • - Review Article

Regulators and Effectors of Arf GTPases in Neutrophils

Jouda Gamara | François Chouinard | ... | Sylvain G. Bourgoin
  • Special Issue
  • - Volume 2015
  • - Article ID 817604
  • - Review Article

The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils

Xuehua Xu | Tian Jin
  • Special Issue
  • - Volume 2015
  • - Article ID 817038
  • - Research Article

Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting

Isabelle Naegelen | Nicolas Beaume | ... | Sabrina Bréchard
  • Special Issue
  • - Volume 2015
  • - Article ID 724982
  • - Research Article

Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women

João Bartholomeu-Neto | Ciro José Brito | ... | Cláudio Córdova
Journal of Immunology Research
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Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.600
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