Journal of Immunology Research

Mycobacterium tuberculosis


Status
Published

1Western University of Health Sciences, Pomona, USA

2Tulane University, Covington, USA


Mycobacterium tuberculosis

Description

M. tb, the causative agent for tuberculosis (TB), is a slow-growing obligated intracellular pathogen infecting one-third of the world’s population. In this population, two billion people are asymptomatic carriers of the bacterial infection. According to WHO, eight million infected individuals will develop active TB and two million will die per year. M. tb infection occurs by inhaling droplets containing M. tb. The innate response to the early stage of infection is mediated by macrophages. However, only in a small proportion of cases does the initial infection progress to overt disease. In most immunocompetent humans, the subsequent expansion of pathogen-specific T-lymphocyte populations results in the evolution of granulomas where the infection is contained but not eradicated. This condition where the infection continues to persist within the host at a subclinical level has been termed latent tuberculosis infection. 10% of individuals who are latently infected with M. tb will undergo reactivation of M. tb infection leading to active disease whenever their immune system gets compromised. A clear understanding of the host immune cell functions will greatly aid in the successful development of a vaccine or an immunomodulatory agent; that can be given as an adjunct to prevent active TB. We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to characterize and understand the host immune responses against M. tb infection. We are particularly interested in the following: articles on cutting-edge research on innate and cell-mediated immune responses against M. tb infection in humans; novel findings from the in vivo studies performed in experimental animals that are relevant to human TB; advances in the discovery of immunomodulatory agents that can enhance the host immune responses to effectively control M. tb infection; and new insights on vaccine discovery.

Potential topics include, but are not limited to:

  • Characterization of the effector mechanisms that are responsible for controlling M. tb infection in human macrophages
  • Elucidating the functions of T-helper subset populations of CD4 T cells (Th1, Th2, Th17, and T-regs) against M. tbinfection
  • Latest breakthroughs in understanding the role of dendritic cells in TB
  • Functions of cytokines and chemokines in modulating the host immune responses against M. tb infection
  • Role of neutrophils in M. tb infection
  • Recent advances in understanding the functions of natural killer cells against M. tb infection
  • Progress made in understanding the roles of natural killer T cells and CD8 T cells in M. tb infection
  • Major headway in the development of vaccine against M. tb
  • Discovery of novel immunomodulatory agents that can be potentially used as an adjunct to prevent TB

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 857598
  • - Editorial

Mycobacterium tuberculosis

Vishwanath Venketaraman | Deepak Kaushal | Beatrice Saviola
  • Special Issue
  • - Volume 2015
  • - Article ID 385402
  • - Research Article

Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis

Selvakumar Subbian | Ruchi Pandey | ... | G. Marcela Rodriguez
  • Special Issue
  • - Volume 2015
  • - Article ID 359153
  • - Research Article

Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults

Piotr Szpakowski | Franck Biet | ... | Magdalena Kowalewicz-Kulbat
  • Special Issue
  • - Volume 2015
  • - Article ID 834749
  • - Research Article

Evaluation of Anti-TBGL Antibody in the Diagnosis of Tuberculosis Patients in China

Jingge Zhao | Zhaoqin Zhu | ... | Toshio Hattori
  • Special Issue
  • - Volume 2015
  • - Article ID 217287
  • - Research Article

Multifunctional Analysis of CD4+ T-Cell Response as Immune-Based Model for Tuberculosis Detection

Miriam Lichtner | Claudia Mascia | ... | Claudio M. Mastroianni
  • Special Issue
  • - Volume 2015
  • - Article ID 793292
  • - Research Article

Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis

Ludmila V. Sakhno | Ekaterina Ya. Shevela | ... | Elena R. Chernykh
  • Special Issue
  • - Volume 2014
  • - Article ID 196124
  • - Research Article

Dose of Incorporated Immunodominant Antigen in Recombinant BCG Impacts Modestly on Th1 Immune Response and Protective Efficiency against Mycobacterium tuberculosis in Mice

Hui Ma | Kang Wu | ... | Xiao-Yong Fan
  • Special Issue
  • - Volume 2014
  • - Article ID 395626
  • - Research Article

A Mycobacterium bovis BCG-Naked DNA Prime-Boost Vaccination Strategy Induced CD4+ and CD8+ T-Cell Response against Mycobacterium tuberculosis Immunogens

Miao Lu | Zhi Yang Xia | Lang Bao
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
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