Journal of Immunology Research

The Cross-Talk between the Bone and the Immune System: Osteoimmunology


Publishing date
19 Jul 2013
Status
Published
Submission deadline
01 Mar 2013

1Section of Human Anatomy and Histology, Department of SMB-NOS, University of Bari, Bari, Italy

2Department of Biomedical Science, University of Foggia, Foggia, Italy

3Department of Medical Sciences, AO Città della Salute e della Scienza, Torino, Italy

4Department of Orthopedics, Washington University School of Medicine, St. Louis, MO, USA


The Cross-Talk between the Bone and the Immune System: Osteoimmunology

Description

In the last decade, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived. On the other hand, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and myeloid dendritic cells. Furthermore, many of the soluble mediators of immune cells, including cytokines, chemokines, and growth factors, regulate the activities of osteoblasts and osteoclasts. This increased recognition of the complex interactions between the immune system and bone led to the development of the interdisciplinary osteoimmunology field. A better understanding of the mechanisms governing the relationship or crosstalk between the skeletal and immune systems has potential for developing new therapeutic strategies for the treatment of disorders characterized by inflammatory bone loss, such as rheumatoid arthritis, bowel disease, osteoporosis, and periodontitis.

We invite investigators to contribute original research papers as well as review papers that will stimulate the continuing efforts to understand the molecular interplay between bone and immune systems. Potential topics include, but are not limited to:

  • Recent developments in the role of osteoblasts in hematopoiesis
  • Advances in the identification of T-cell subset influencing osteoclast differentiation
  • Cytokines and local immune cell factors as regulators of bone cell functions in basal or pathological conditions
  • Immune cells as mediators of hormonal effects on bone cells
  • Role of the immune system in arthritis, cancer, osteoporosis, and other bone diseases
  • Recent advances in role of osteoblasts in bone marrow cell transplantation
  • Latest therapeutic strategies targeting osteoimmunology pathways

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/author/submit/journals/cdi/osteo/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 617319
  • - Editorial

The Crosstalk between the Bone and the Immune System: Osteoimmunology

Giacomina Brunetti | Giorgio Mori | ... | Roberta Faccio
  • Special Issue
  • - Volume 2013
  • - Article ID 203705
  • - Review Article

Th17 and Treg Cells in Bone Related Diseases

Min Wang | Tian Tian | ... | Daoxin Ma
  • Special Issue
  • - Volume 2013
  • - Article ID 720504
  • - Review Article

The Interplay between the Bone and the Immune System

Giorgio Mori | Patrizia D'Amelio | ... | Giacomina Brunetti
  • Special Issue
  • - Volume 2013
  • - Article ID 945945
  • - Review Article

Bone Effects of Biologic Drugs in Rheumatoid Arthritis

Addolorata Corrado | Anna Neve | ... | Francesco Paolo Cantatore
  • Special Issue
  • - Volume 2013
  • - Article ID 429373
  • - Review Article

Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems

Zachary S. Buchwald | Rajeev Aurora
  • Special Issue
  • - Volume 2013
  • - Article ID 382698
  • - Review Article

FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis

Graziana Colaianni | Concetta Cuscito | Silvia Colucci
  • Special Issue
  • - Volume 2013
  • - Article ID 289458
  • - Review Article

Cellular Mechanisms of Multiple Myeloma Bone Disease

Angela Oranger | Claudia Carbone | ... | Maria Grano
  • Special Issue
  • - Volume 2013
  • - Article ID 575936
  • - Review Article

Postmenopausal Osteoporosis: The Role of Immune System Cells

Maria Felicia Faienza | Annamaria Ventura | ... | Luciano Cavallo
  • Special Issue
  • - Volume 2013
  • - Article ID 181849
  • - Review Article

Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone Resorption In Vitro and In Vivo

Hideki Kitaura | Keisuke Kimura | ... | Teruko Takano-Yamamoto
  • Special Issue
  • - Volume 2013
  • - Article ID 503754
  • - Review Article

Periodontal Disease: Linking the Primary Inflammation to Bone Loss

Adriana Di Benedetto | Isabella Gigante | ... | Maria Grano
Journal of Immunology Research
 Journal metrics
Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.100
Impact Factor3.327
 Submit

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.