Journal of Immunology Research

The Role of TH17-Associated Cytokines in Health and Disease


Publishing date
02 Aug 2013
Status
Published
Submission deadline
15 Mar 2013

1Center for Immunology and Microbial Disease, Albany Medical College, Albany, USA

2Immunology Institute, Mount Sinai School of Medicine, Icahn Medical Institute, New York, USA

3Medical Department University Hospital, Hamburg, Eppendorf, Martinistr, Hamburg, Germany


The Role of TH17-Associated Cytokines in Health and Disease

Description

Effector CD4+ T cells of the TH17-type coordinate inflammatory episodes, primarily at mucosal surfaces, through secreted effector cytokines. When improperly regulated these cytokines have the capacity to initiate or contribute to inflammation-mediated pathology in a variety of organ systems. Indeed TH17 cells have been implicated in numerous autoimmune and autoinflammatory disorders in mice and men, including multiple sclerosis, psoriasis, rheumatoid arthritis, the inflammatory bowel diseases, and uveitis, to name a few. As such, TH17-associated factors are currently prime targets for therapeutic intervention.

Among the well-studied TH17-associated factors are several interleukins, including IL-17 family proteins and IL-22. These cytokines are critical for proper host defense against Gram-positive and Gram-negative bacteria as well as parasitic and fungal pathogens. It is now widely appreciated, however, that these cytokines are multifunctional and influence a variety of distinct biological processes. In addition to eliciting antimicrobial peptide production and recruiting neutrophils and other immune cells to an inflammatory site, these cytokines modulate myeloid, lymphoid, and epithelial cell function, vascular remodeling, and even granulopoiesis.

We are interested in articles that highlight the ways in which these factors contribute to the initiating as well as resolving phases of inflammation, mediating host control of invading pathogens while coordinating mucosal healing and tissue repair.

We encourage investigators to submit original research manuscripts as well as review articles on all aspects of IL -17 and IL-22 biology; we are particularly interested in articles that focus on the regulatory nature of these cytokines during inflammation. Potential topics include, but are not limited to:

  • The role of TH17-associated cytokines in the inflammatory bowel diseases (IBDs)
  • The contribution of TH17-associated cytokines to autoimmune disease processes in rheumatoid arthritis, multiple sclerosis, and others
  • Defining the contribution of IL-17 proteins in inflammatory episodes in skin
  • Identifying key factors that modulate TH17 cell pathogenicity
  • The impact of non-TH17 cell sources of TH17-associated cytokines in mucosal immunity and host defense (i.e., gamma delta T cells, innate lymphoid cells, etc.)
  • The role of TH17-associated cytokines in the progression to neoplasia
  • Novel strategies to alter TH17 cell function for clinical benefit

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jir/tchd/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 936270
  • - Editorial

The Role of TH17-Associated Cytokines in Health and Disease

William O’Connor | Enric Esplugues | Samuel Huber
  • Special Issue
  • - Volume 2014
  • - Article ID 602846
  • - Review Article

Potential Involvement of IL-17F in Asthma

Kyoko Ota | Mio Kawaguchi | ... | Nobuyuki Hizawa
  • Special Issue
  • - Volume 2013
  • - Article ID 957878
  • - Review Article

The Multifaceted Role of Th17 Lymphocytes and Their Associated Cytokines in Cancer

Darya Alizadeh | Emmanuel Katsanis | Nicolas Larmonier
  • Special Issue
  • - Volume 2013
  • - Article ID 609395
  • - Review Article

Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma

Yuko Morishima | Satoshi Ano | ... | Nobuyuki Hizawa
  • Special Issue
  • - Volume 2013
  • - Article ID 253046
  • - Research Article

Anti-IL-17 Antibody Improves Hepatic Steatosis by Suppressing Interleukin-17-Related Fatty Acid Synthesis and Metabolism

Weidong Shi | Qiang Zhu | ... | Guoqiang Li
  • Special Issue
  • - Volume 2013
  • - Article ID 374769
  • - Review Article

The Role of T Helper ( )17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation

Nasr Y. A. Hemdan | Ahmed M. Abu El-Saad | Ulrich Sack
  • Special Issue
  • - Volume 2013
  • - Article ID 915873
  • - Clinical Study

Aberrant T Helper 17 Cells and Related Cytokines in Bone Marrow Microenvironment of Patients with Acute Myeloid Leukemia

Tian Tian | Shuang Yu | ... | Daoxin Ma
  • Special Issue
  • - Volume 2013
  • - Article ID 267971
  • - Review Article

IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection

Hsing-Chuan Tsai | Sharlene Velichko | ... | Reen Wu
  • Special Issue
  • - Volume 2013
  • - Article ID 968549
  • - Review Article

Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases

Ning Qu | Mingli Xu | ... | Takayuki Yoshimoto
  • Special Issue
  • - Volume 2013
  • - Article ID 852418
  • - Review Article

Loss and Dysregulation of Th17 Cells during HIV Infection

Sandra L. Bixler | Joseph J. Mattapallil
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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