Journal of Immunology Research

Inflammation in the Tumor Microenvironment


Status
Published

Lead Editor

1Johns Hopkins University, Baltimore, USA

2University of Florida, Gainesville, USA

3University of Chicago, Chicago, USA

4Nanchang University, Nanchang, China

5Shantou University, Shantou, China


Inflammation in the Tumor Microenvironment

Description

Breakdown of immune homeostasis, either diminished or exacerbated innate immune signaling, may trigger inflammation-associated cancer. The interaction between immune cells, their soluble mediators, genetically altered cells and host structural components resulted in the production of an intricate and heterogeneous complex of cells and matrix that forms the tumor microenvironment. Inflammation in the tumor microenvironment affects every aspect of tumor development and progression as well as the response to therapy. Inflammatory cellular effectors and cytokines within the tumor microenvironment can promote an antitumor immune response or support tumor pathogenesis. Similarly the multiprotein complex inflammasome may eliminate malignant cells via the inflammatory type of programmed cell death, termed pyroptosis, or favor the production of growth and trophic factors for tumor cells. Chronic inflammation also induces genetic and epigenetic alterations of various protooncogenes and tumor-suppressor factors through various mechanisms. In addition, inflammation-related angiogenic milieu regulates tumor survival and tolerance. Given the multifaceted role of inflammation in cancer, a better understanding of the tumor-associated inflammatory signaling and their microenvironmental cross-talk and network is crucial for elucidating tumorigenesis mechanisms and for cancer therapy, prevention, and risk assessment.

In the proposed special issue, we will invite authors to present original research articles as well as review articles on elucidating the signaling network and pathological significance of inflammatory tumor microenvironment that controls the induction, progression, and therapies of cancers. We are particularly interested in articles investigating the role of the essential microenvironmental elements including inflammatory mediators and cellular effectors, multimeric protein complexes (inflammasomes), genomic alterations (genetics and epigenetics), and angiogenesis (vascular stromal components) in the context of cancer-related inflammatory processes and the new insights into tumor immunotherapy, which will help explore new target or approach for cancer treatment, by either boosting antitumor immunity or subverting tumor-educated immunosuppression.

Potential topics include but are not limited to the following:

  • Inflammatory signaling bridging homeostasis disruption and tumorigenesis
  • Vascular inflammation in tumor microenvironment
  • Inflammasomes in the tumor microenvironment
  • New basic/translational insights in tumor immunotherapy
  • New clinical insights in tumor immunotherapy
  • Wound microenvironment and tumorigenesis
  • Genetic and epigenetic modulation in inflammatory tumor microenvironment
  • Tumor-infiltrating leukocytes
  • Cytokine signaling in the tumor microenvironment
  • Inflammatory biomarkers in the tumor microenvironment

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 1965847
  • - Editorial

Inflammation in the Tumor Microenvironment

Qing Lin | Shi Jin | ... | Xiaolong Wei
  • Special Issue
  • - Volume 2018
  • - Article ID 4925498
  • - Research Article

A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma

Qiaodong Xu | Yongcong Yan | ... | Zhiyu Xiao
  • Special Issue
  • - Volume 2018
  • - Article ID 8740976
  • - Review Article

Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations

Yingjun Xie | Yien Xiang | ... | Xuewen Zhang
  • Special Issue
  • - Volume 2018
  • - Article ID 7132868
  • - Research Article

Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population

Guangcan Chen | Muming Xu | ... | Shuhui Liu
  • Special Issue
  • - Volume 2018
  • - Article ID 2584243
  • - Review Article

Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer

Angélica Aponte-López | Ezequiel M. Fuentes-Pananá | ... | Samira Muñoz-Cruz
  • Special Issue
  • - Volume 2018
  • - Article ID 4564328
  • - Research Article

STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone

Shuxin Chen | Zepeng Du | ... | Zhigang Zhong
  • Special Issue
  • - Volume 2017
  • - Article ID 1832968
  • - Review Article

Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies

Giovanni D’Arena | Candida Vitale | ... | Daniela Fenoglio
  • Special Issue
  • - Volume 2017
  • - Article ID 7979637
  • - Review Article

Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers

Geou-Yarh Liou
  • Special Issue
  • - Volume 2017
  • - Article ID 1278081
  • - Research Article

The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis

Mingfa Liu | Zhennan Xu | ... | Haixiong Xu
  • Special Issue
  • - Volume 2017
  • - Article ID 4302320
  • - Research Article

Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation

Wen Zeng | Hanjun Dai | ... | Zeming Liu
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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